Evidence map›Paper›PMID 33397104›Full record

ArticleJournal of the American Chemical Society2021

Theoretical Description of the Primary Proton-Coupled Electron Transfer Reaction in the Cytochrome

Angela M Barragan, Alexander V Soudackov, Zaida Luthey-Schulten, Sharon Hammes-Schiffer, Klaus Schulten, Ilia A Solov'yov

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Chemical Society, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 36 citations in OpenAlex.

  1. Review
  2. Article
  3. Catabolic Mechanism of 17β-Estradiol inJournal of microbiology and biotechnology · 2026
    Article
  4. Flexibility and Hydration of the QJournal of chemical information and modeling · 2025
    Article
  5. Redox-Activated Proton Transfer through a Redundant Network in the QJournal of chemical information and modeling · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Angela M BarraganNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, United States.
Alexander V SoudackovDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.ORCID 0000-0001-9581-8494
Zaida Luthey-SchultenNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, United States.
Sharon Hammes-SchifferDepartment of Chemistry, Yale University, 225 Prospect Street, New Haven, Connecticut 06520, United States.ORCID 0000-0002-3782-6995
Klaus SchultenNIH Center for Macromolecular Modeling and Bioinformatics, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, 405 North Mathews Avenue, Urbana, Illinois 61801, United States.
Ilia A Solov'yovDepartment of Physics, Carl von Ossietzky University, Carl-von-Ossietzky-Strasse 9-11, Oldenburg 26111, Germany.ORCID 0000-0002-8626-145X
University of Illinois Urbana-Champaign · USYale University · USCarl von Ossietzky Universität Oldenburg · DE

Funding

WHOLE CELL SIMULATIONP41GM104601 · NIGMS · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI TAJKHORSHID, EMAD · 2012 to 2021
$19.0M
Simulation of Proton and Hydride Transfer in EnzymesR37GM056207 · NIGMS · YALE UNIVERSITY · PI HAMMES-SCHIFFER, SHARON · 2011 to 2020
$3.2M
SIMULATION OF PROTON AND HYDRIDE TRANSFER IN ENZYMESR01GM056207 · NIGMS · UNIVERSITY OF NOTRE DAME · PI HAMMES-SCHIFFER, SHARON · 1998 to 2010
$2.7M
NIGMS NIH HHS P41 GM104601NIGMS NIH HHS R01 GM056207NIGMS NIH HHS R37 GM056207
6 · The paper itself

Abstract

The cytochrome

Indexed as

Quantum TheoryCytochromes bCytochromes c1Electron TransportKineticsProtonsSurface PropertiesCytochromes bCytochromes c1Protons

Identifiers

PMID33397104
PMCPMC8037953
OpenAlexW3119789431

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.