Evidence map›Paper›PMID 33396564›Full record

ReviewInternational journal of molecular sciences2020

Neuropsychiatric Disorders Due to Limbic Encephalitis: Immunologic Aspect.

Yu-Chia Kao, Ming-I Lin, Wen-Chin Weng, Wang-Tso Lee

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.4field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 32 citations in OpenAlex.

  1. Lactate acts as a metabolic brake on inflammation by repressing NLRP3 transcription via NF-κB inhibition.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Yu-Chia KaoDepartment of Pediatrics, E-Da Hospital, Kaohsiung 82445, Taiwan.ORCID 0000-0002-9486-2597
Ming-I LinDepartment of Pediatrics, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 11101, Taiwan.ORCID 0000-0001-8100-8300
Wen-Chin WengDepartment of Pediatrics, National Taiwan University Hospital, Taipei 100226, Taiwan.ORCID 0000-0002-6923-9138
Wang-Tso LeeDepartment of Pediatrics, National Taiwan University Hospital, Taipei 100226, Taiwan.
National Taiwan University · TWE-Da Hospital · TW

Funding

E-Da Hospital National Taiwan University Hospital Joint Research Program 100-EDN03, 101-EDN01National Cheng-Kung University E-Da Hospital Joint Program NCKUEDA10211
6 · The paper itself

Abstract

Limbic encephalitis (LE) is a rare cause of encephalitis presenting as an acute and subacute onset of neuropsychiatric manifestations, particularly with memory deficits and confusion as core features, along with seizure occurrence, movement disorders, or autonomic dysfunctions. LE is caused by neuronal antibodies targeting the cellular surface, synaptic, and intracellular antigens, which alter the synaptic transmission, especially in the limbic area. Immunologic mechanisms involve antibodies, complements, or T-cell-mediated immune responses in different degree according to different autoantibodies. Sensitive cerebrospinal fluid markers of LE are unavailable, and radiographic findings may not reveal a typical mesiotemporal involvement at neurologic presentations; therefore, a high clinical index of suspicions is pivotal, and a neuronal antibody testing is necessary to make early diagnosis. Some patients have concomitant tumors, causing paraneoplastic LE; therefore, tumor survey and treatment are required in addition to immunotherapy. In this study, a review on the molecular and immunologic aspects of LE was conducted to gain awareness of its peculiarity, which we found quite different from our knowledge on traditional psychiatric illness.

Indexed as

AnimalsHumansLimbic EncephalitisMental DisordersNeuropsychological Testslimbic encephalitisneuronal cell-surface antibodyneuropsychiatriconconeural antibodyparaneoplastic neurologic syndrome

Identifiers

PMID33396564
PMCPMC7795533
OpenAlexW3115079956

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.