ArticleJournal of personalized medicine2020
Thermal Liquid Biopsy (TLB) Focused on Benign and Premalignant Pancreatic Cyst Diagnosis.
Article in Journal of personalized medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Article
- Thermal Liquid Biopsy: A Promising Tool for the Differential Diagnosis of Pancreatic Cystic Lesions and Malignancy Detection.Cancers · 2024Article
- Characterization of myocardial injury phenotype by thermal liquid biopsy.Frontiers in cardiovascular medicine · 2024Article
- Plasma Thermogram Parameters Differentiate Status and Overall Survival of Melanoma Patients.Current oncology (Toronto, Ont.) · 2023Article
- Article
- Predictive genomic tools in disease stratification and targeted prevention: a recent update in personalized therapy advancements.The EPMA journal · 2022Review
- Liquid biopsy: early and accurate diagnosis of brain tumor.Journal of cancer research and clinical oncology · 2022Review
- Review
- Special Issue: "Gastrointestinal Cancers and Personalized Medicine".Journal of personalized medicine · 2022Article
- Fluorescence Liquid Biopsy for Cancer Detection Is Improved by Using Cationic Dendronized Hyperbranched Polymer.International journal of molecular sciences · 2021Article
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Authors and funding
11 authors.
Funding
Abstract
backgroundCurrent efforts in the identification of new biomarkers are directed towards an accurate differentiation between benign and premalignant cysts. Thermal Liquid Biopsy (TLB) has been previously applied to inflammatory and tumor diseases and could offer an interesting point of view in this type of pathology.
methodsIn this work, twenty patients (12 males and 8 females, average ages 62) diagnosed with a pancreatic cyst benign (10) and premalignant (10) cyst lesions were recruited, and biological samples were obtained during the endoscopic ultrasonography procedure.
resultsProteomic content of cyst liquid samples was studied and several common proteins in the different groups were identified. TLB cyst liquid profiles reflected protein content. Also, TLB serum score was able to discriminate between healthy and cysts patients (71% sensitivity and 98% specificity) and between benign and premalignant cysts (75% sensitivity and 67% specificity).
conclusionsTLB analysis of plasmatic serum sample, a quick, simple and non-invasive technique that can be easily implemented, reports valuable information on the observed pancreatic lesion. These preliminary results set the basis for a larger study to refine TLB serum score and move closer to the clinical application of TLB providing useful information to the gastroenterologist during patient diagnosis.
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Registered trials
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