Evidence map›Paper›PMID 33396516›Full record

ArticleMolecules (Basel, Switzerland)2020

Studies of Coumarin Derivatives for Constitutive Androstane Receptor (CAR) Activation.

Shin-Hun Juang, Min-Tsang Hsieh, Pei-Ling Hsu, Ju-Ling Chen, Hui-Kang Liu, Fong-Pin Liang, Sheng-Chu Kuo, Chen-Yuan Chiu, Shing-Hwa Liu, Chen-Hsi Chou and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Coumarin and Its Derivatives-Editorial.Molecules (Basel, Switzerland) · 2021
    Article
  3. Frontiers in endocrinology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Shin-Hun JuangSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.
Min-Tsang HsiehSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.ORCID 0000-0001-7287-9278
Pei-Ling HsuSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.
Ju-Ling ChenSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.
Hui-Kang LiuNational Research Institute of Chinese Medicine, Ministry of Health and Welfare, Taipei 112, Taiwan.ORCID 0000-0002-5297-6836
Fong-Pin LiangSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.
Sheng-Chu KuoSchool of Pharmacy, China Medical University, Taichung 404, Taiwan.
Chen-Yuan ChiuGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0003-4378-993X
Shing-Hwa LiuGraduate Institute of Toxicology, College of Medicine, National Taiwan University, Taipei 100, Taiwan.ORCID 0000-0002-9976-1197
Chen-Hsi ChouSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0003-0708-3657
Tian-Shung WuSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Hsin-Yi HungSchool of Pharmacy, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.ORCID 0000-0001-7666-2420
China Medical University · TWNational Cheng Kung University · TWNational Taiwan University · TWNational Research Institute of Chinese Medicine · TW

Funding

Ministry of Science and Technology, Taiwan MOST
6 · The paper itself

Abstract

Constitutive androstane receptor (CAR) activation has found to ameliorate diabetes in animal models. However, no CAR agonists are available clinically. Therefore, a safe and effective CAR activator would be an alternative option. In this study, sixty courmarin derivatives either synthesized or purified from

Indexed as

AnimalsCarcinoma, HepatocellularConstitutive Androstane ReceptorCoumarinsDiabetes Mellitus, ExperimentalErbB ReceptorsHumansLiver NeoplasmsMaleMiceMice, Inbred C57BLProtein Phosphatase 2CReceptors, Cytoplasmic and NuclearTumor Cells, CulturedConstitutive Androstane ReceptorCoumarinsEGFR protein, humanErbB ReceptorsPPM1A protein, humanProtein Phosphatase 2CReceptors, Cytoplasmic and Nuclearconstitutive androstane receptorcoumarinscoparoneYin Chen Hao

Identifiers

PMID33396516
PMCPMC7796031
OpenAlexW3113983857

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.