Evidence map›Paper›PMID 33396463›Full record

ArticleInternational journal of molecular sciences2020

MMP1 and MMP11 Expression in Peripheral Blood Mononuclear Cells upon Their Interaction with Breast Cancer Cells and Fibroblasts.

Noemi Eiro, Sandra Cid, Nuria Aguado, María Fraile, Nagore de Pablo, Berta Fernández, Francisco Domínguez, Luis O González, Francisco J Vizoso

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Noemi EiroResearch Unit, Fundación Hospital de Jove, 33290 Gijón, Spain.ORCID 0000-0001-5840-4807
Sandra CidResearch Unit, Fundación Hospital de Jove, 33290 Gijón, Spain.
Nuria AguadoDepartment of Surgery, Hospital Universitario San Agustín, 33401 Avilés, Spain.
María FraileResearch Unit, Fundación Hospital de Jove, 33290 Gijón, Spain.ORCID 0000-0002-0092-7805
Nagore de PabloResearch Unit, Fundación Hospital de Jove, 33290 Gijón, Spain.
Berta FernándezDepartment of Surgery, Hospital Universitario Central de Asturias, 33011 Oviedo, Spain.
Francisco DomínguezDepartment of Anatomical Pathology, Hospital Universitario de Cabueñes, 33394 Gijón, Spain.
Luis O GonzálezDepartment of Anatomical Pathology, Fundación Hospital de Jove, 33209 Gijón, Spain.
Francisco J VizosoResearch Unit, Fundación Hospital de Jove, 33290 Gijón, Spain.ORCID 0000-0002-2827-5511
Fundación Hospital de Jove · ESHospital Universitario Central de Asturias · ESHospital Universitario De Cabueñes · ESHospital Universitario San Agustín · ES

Funding

ERDF/ESF "Investing in your future"Instituto de Salud Carlos III PI13/02745Instituto de Salud Carlos III PI17/02236"Severo Ochoa" PhD Program from Gobierno del Principado de Asturias BP14-128
6 · The paper itself

Abstract

Tumor-infiltrating immune cells phenotype is associated with tumor progression. However, little is known about the phenotype of the peripheral blood mononuclear cells (PBMC) from breast cancer patients. We investigated MMP1 and MMP11 expression in PBMC from breast cancer patients and we analyzed gene expression changes upon their interaction with cancer cells and cancer-associated fibroblasts (CAF). We measured the impact of PBMC on proinflammatory gene expression in breast cancer cells, normal fibroblast (NF), and CAF and the impact on proliferation and invasiveness capacity of breast cancer cells. Gene expression of MMP1 and MMP11 in PBMC from breast cancer patients (

Indexed as

Gene Expression Regulation, EnzymologicBiomarkers, TumorBreast NeoplasmsCancer-Associated FibroblastsCase-Control StudiesCoculture TechniquesErb-b2 Receptor Tyrosine KinasesFemaleFibroblastsFollow-Up StudiesGene Expression Regulation, NeoplasticHumansLeukocytes, MononuclearMatrix Metalloproteinase 1Matrix Metalloproteinase 11Middle AgedBiomarkers, TumorERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesMatrix Metalloproteinase 1Matrix Metalloproteinase 11MMP11 protein, humanMMP1 protein, humanReceptors, EstrogenReceptors, Progesteronebreast cancerinflammation and cancerinflammatory cellsPBMCstroma

Identifiers

PMID33396463
PMCPMC7795480
OpenAlexW3113667661

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.