Evidence map›Paper›PMID 33396408›Full record

ArticleInternational journal of molecular sciences2020

Multi-Omics Characterization of Inflammatory Bowel Disease-Induced Hyperplasia/Dysplasia in the

Qiyuan Han, Thomas J Y Kono, Charles G Knutson, Nicola M Parry, Christopher L Seiler, James G Fox, Steven R Tannenbaum, Natalia Y Tretyakova

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Qiyuan HanDepartment of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, MN 55455, USA.ORCID 0000-0002-1625-6268
Thomas J Y KonoMinnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN 55455, USA.
Charles G KnutsonDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Nicola M ParryDivision of Comparative Medicine, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Christopher L SeilerDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
James G FoxDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Steven R TannenbaumDepartment of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
Natalia Y TretyakovaDepartment of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.
Massachusetts Institute of Technology · USUniversity of Minnesota · US

Funding

Smoking-Induced Epigenetic Changes in the Lung: Role of DNA DemethylationR01CA095039 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI TRETYAKOVA, NATALIA Y · 2003 to 2022
$3.6M
Sequence Distribution of Tabacco Carcinogen-DNA AdductsR56CA095039 · NCI · UNIVERSITY OF MINNESOTA · PI TRETYAKOVA, NATALIA Y · 2007 to 2007
$237k
Division of Cancer Epidemiology and Genetics, National Cancer Institute CA-095039NCI NIH HHS R01 CA095039
6 · The paper itself

Abstract

Epigenetic dysregulation is hypothesized to play a role in the observed association between inflammatory bowel disease (IBD) and colon tumor development. In the present work, DNA methylome, hydroxymethylome, and transcriptome analyses were conducted in proximal colon tissues harvested from the

Indexed as

DNA MethylationGene Expression RegulationTranscriptomeAnimalsDisease Models, AnimalDNA-Binding ProteinsEpigenomicsFemaleHyperplasiaInflammatory Bowel DiseasesInterleukin-10MaleMiceMice, KnockoutPromoter Regions, GeneticDNA-Binding ProteinsIL10 protein, mouseInterleukin-10Rag2 protein, mousecolorectal cancerdysplasiahydroxymethylomehyperplasiainflammatory bowel diseasemethylomemulti omics analysis and integrationtranscriptome

Identifiers

PMID33396408
PMCPMC7795000
OpenAlexW3114694596

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.