Evidence map›Paper›PMID 33396315›Full record

ArticleCancers2020

Analysis of the TCGA Dataset Reveals that Subsites of Laryngeal Squamous Cell Carcinoma are Molecularly Distinct.

Alana Sorgini, Hugh Andrew Jinwook Kim, Peter Y F Zeng, Mushfiq Hassan Shaikh, Neil Mundi, Farhad Ghasemi, Eric Di Gravio, Halema Khan, Danielle MacNeil, Mohammed Imran Khan and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 20 citations in OpenAlex.

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  14. Association of TP53 and CDKN2A Mutation Profile with Tumor Mutation Burden in Head and Neck Cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 3 institutions in 2 countries.

Alana SorginiDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0002-4796-5286
Hugh Andrew Jinwook KimDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Peter Y F ZengDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Mushfiq Hassan ShaikhDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0001-9953-3939
Neil MundiDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0001-9328-8266
Farhad GhasemiDepartment of General Surgery, University of Western Ontario, London, ON N6A 5C5, Canada.
Eric Di GravioDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Halema KhanDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Danielle MacNeilDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Mohammed Imran KhanDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0003-3020-1324
Adrian MendezDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
John YooDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Kevin FungDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Pencilla LangDepartment of Oncology, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0003-3156-4450
David A PalmaDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Joe S MymrykDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0002-3521-8005
John W BarrettDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.
Krupal B PatelDepartment of Otolaryngology, Moffitt Cancer Center, Tampa, FL 33612, USA.ORCID 0000-0002-2285-0386
Paul C BoutrosDepartment of Human Genetics, University of California, Los Angeles, CA 90095, USA.ORCID 0000-0003-0553-7520
Anthony C NicholsDepartment of Otolaryngology, Head and Neck Surgery, University of Western Ontario, London, ON N6A 5W9, Canada.ORCID 0000-0002-0760-980X
Western University · CAMoffitt Cancer Center · USUniversity of California, Los Angeles · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
CIHR MOP 340674Division of Cancer Epidemiology and Genetics, National Cancer Institute P30CA016042Wolfe Surgical Research Professorship Biology of Head and Neck Cancers Fund
6 · The paper itself

Abstract

Laryngeal squamous cell carcinoma (LSCC) from different subsites have distinct presentations and prognosis. In this study, we carried out a multiomic comparison of LSCC subsites. The Cancer Genome Atlas (TCGA) LSCC cohort was analyzed in the R statistical environment for differences between supraglottic and glottic cancers in single nucleotide variations (SNVs), copy number alterations (CNAs), mRNA abundance, protein abundance, pathway overrepresentation, tumor microenvironment (TME), hypoxia status, and patient outcome. Supraglottic cancers had significantly higher overall and smoking-associated SNV mutational load. Pathway analysis revealed upregulation of muscle related pathways in glottic cancer and neural pathways in supraglottic cancer. Proteins involved in cancer relevant signaling pathways including PI3K/Akt/mTOR, the cell cycle, and PDL1 were differentially abundant between subsites. Glottic and supraglottic tumors have different molecular profiles, which may partially account for differences in presentation and response to therapy.

Indexed as

genomicsHNSCCHPV-negativelarynx cancermutational status

Identifiers

PMID33396315
PMCPMC7794818
OpenAlexW3114184848

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.