Evidence map›Paper›PMID 33396308›Full record

ArticleViruses2020

Protein Disulfide Isomerase A4 Is Involved in Genome Uncoating during Human Astrovirus Cell Entry.

Nayeli Aguilar-Hernández, Lena Meyer, Susana López, Rebecca M DuBois, Carlos F Arias

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
0.5field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 25 citations in OpenAlex.

  1. Article
  2. Article
  3. Neonatal Fc receptor is a functional receptor for classical human astrovirus.Genes to cells : devoted to molecular & cellular mechanisms · 2024
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Structure of the divergent human astrovirus MLB capsid spike.Structure (London, England : 1993) · 2022
    Article
  11. Review
  12. Article
  13. Review
  14. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Nayeli Aguilar-HernándezDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca CP 62210, Mexico.
Lena MeyerDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA.
Susana LópezDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca CP 62210, Mexico.ORCID 0000-0001-6336-9209
Rebecca M DuBoisDepartment of Biomolecular Engineering, University of California, Santa Cruz, CA 95064, USA.
Carlos F AriasDepartamento de Genética del Desarrollo y Fisiología Molecular, Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca CP 62210, Mexico.ORCID 0000-0003-3130-4501
Universidad Nacional Autónoma de México · MXUniversity of California, Santa Cruz · US

Funding

Structural, mechanistic, and antigenic insights into the human astrovirus capsidR01AI144090 · NIAID · UNIVERSITY OF CALIFORNIA SANTA CRUZ · PI DUBOIS, REBECCA MICHELLE · 2019 to 2023
$2.2M
NIAID NIH HHS R01 AI144090NIH HHS R01AI144090
6 · The paper itself

Abstract

Although human astroviruses (HAstVs) are important agents of gastroenteritis in young children, the studies aimed at characterizing their biology have been limited, in particular regarding their cell entry process. It has been shown that HAstV serotype 8 enters human cells by a classical clathrin-mediated endocytosis pathway; however, the cell receptor or other cell entry factors that may be relevant for an efficient viral infection are unknown. In this work we used a far-Western blotting approach to identify cellular proteins that interact with the recombinant capsid spike proteins of HAstV serotypes 1, 2, and 8, synthesized in

Indexed as

Host-Pathogen InteractionsVirus UncoatingAstroviridae InfectionsCapsid ProteinsCell LineCells, CulturedHumansMamastrovirusProtein BindingProtein Disulfide-IsomerasesVirus InternalizationCapsid ProteinsPDIA4 protein, humanProtein Disulfide-Isomerasesastrovirusprotein disulfide isomerasevirus entry

Identifiers

PMID33396308
PMCPMC7824429
OpenAlexW3118091331

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.