Evidence map›Paper›PMID 33396243›Full record

ArticleChildren (Basel, Switzerland)2020

Cerebral Palsy and Epilepsy in Children: Clinical Perspectives on a Common Comorbidity.

Piero Pavone, Carmela Gulizia, Alice Le Pira, Filippo Greco, Pasquale Parisi, Giuseppe Di Cara, Raffaele Falsaperla, Riccardo Lubrano, Carmelo Minardi, Alberto Spalice and 1 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Children (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06064357 (Comparison of Massage Therapy and Tissue Flossing Technique in Children With Diplegic Cerebral Palsy), which is not on this map. Cited by 25 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed, 1 pooled it
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06064357 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Comparison of Massage Therapy and Tissue Flossing Technique in Children With Diplegic Cerebral Palsy

TypeinterventionalSponsorRiphah International UniversityRan2023 to 2024Enrolled56ConditionsSpastic Diplegia Cerebral PalsyArmsTransverese friction massage and tissue floss technique
3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.

  1. Pooled it
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  8. Patient Selection in Selective Dorsal Rhizotomy (SDR).Advances and technical standards in neurosurgery · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Piero PavoneUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU "Policlinico", PO "G. Rodolico", University of Catania, 95123 Catania, Italy.ORCID 0000-0002-5600-9560
Carmela GuliziaPostgraduate Training Program in Pediatrics, Department of Clinical and Experimental Medicine, University of Catania, 95123 Catania, Italy.
Alice Le PiraUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU "Policlinico", PO "G. Rodolico", University of Catania, 95123 Catania, Italy.
Filippo GrecoUnit of Clinical Pediatrics, Department of Clinical and Experimental Medicine, AOU "Policlinico", PO "G. Rodolico", University of Catania, 95123 Catania, Italy.
Pasquale ParisiNESMOS Department of Pediatrics, Sapienza University of Rome, Sant'Andrea University Hospital, 00161 Rome, Italy.ORCID 0000-0001-9042-8120
Giuseppe Di CaraDepartment of Pediatrics, University of Perugia, 06132 Perugia, Italy.
Raffaele FalsaperlaNeonatal Intensive Care Unit (NICU), Neonatal COVID-19 Center, AOU "Policlinico", PO San Marco, University of Catania, 95123 Catania, Italy.
Riccardo LubranoDipartimento Materno Infantile e di Scienze Urologiche, Sapienza Università di Roma, UOC di Pediatria, Neonatologia, Ospedale Santa Maria Goretti, Polo di Latina, 04010 Latina, Italy.
Carmelo MinardiDepartment of Anaesthesia and Intensive Care, University Hospital "G. Rodolico" of Catania, 95123 Catania, Italy.ORCID 0000-0001-5355-1648
Alberto SpaliceChild Neurology Division, Department of Pediatrics, Sapienza University of Rome, 00161 Rome, Italy.
Martino RuggieriUnit of Rare Diseases of the Nervous System in Childhood, Department of Clinical and experimental Medicine, Section of Pediatrics and Child Neuropsychiatry, University of Catania, 95123 Catania, Italy.
University of Catania · ITAzienda Ospedaliera Sant'Andrea · ITOspedale Santa Maria Goretti · ITSapienza University of Rome · ITUniversity of Perugia · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cerebral palsy (CP) is a frequent cause of childhood disability often associated with a complex group of disorders, including epilepsy, which is reported to impact approximately 40% of affected individuals. This retrospective study involved a group of children affected by CP, some of whom also had comorbid epilepsy. The aim of this study was to report our experience of analyzing, in particular, (a) some of the clinical aspects of the different type of CP, and (b) the relationship between the clinical data of children affected by CP plus epilepsy and each type of CP.

methodsThis retrospective single-center study was performed with 93 children admitted to the Pediatric Department of the University of Catania, Italy, affected by CP and distinguished according to the type of motor clinical presentation, with 46 showing epileptic seizures, compared to a control group of 136 children affected by epilepsy without other neurologic disorders.

resultsAmong the 93 CP children, 25 (27%) had spastic quadriplegia (plus one patient with dystonic quadriplegia), 39 (42%) had spastic hemiplegia, 11 (12%) had spastic diplegia (plus two with ataxia and one with dyskinetic CP), and 14 (15%) did not have a well-defined type of CP. The frequency of epilepsy was higher in affected CP children who showed major motor dysfunction (GMFCS IV-V types). As regards the 46 children with CP plus epilepsy, compared to the group of the control, the age of epilepsy onset was found to be statistically significant: 21 ± 35.1 months vs. 67 ± 39.7.

conclusionsEpilepsy represents one of the most frequent comorbidities of cerebral palsy. In children with CP, particular attention should be paid to the early identification and treatment of comorbid epilepsy.

Indexed as

cerebral palsyepilepsyhemiplegiaquadriplegiaseizures

Identifiers

PMID33396243
PMCPMC7823826
OpenAlexW3113499867

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.