ArticleLife (Basel, Switzerland)2020
Dependence of Leydig Cell's Mitochondrial Physiology on Luteinizing Hormone Signaling.
Article in Life (Basel, Switzerland), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 32 citations in OpenAlex.
- Microsomal triglyceride transfer protein restricts steroid production in Leydig cells by regulating SREBP2.iScience · 2026Article
- Natural astaxanthin enhances testosterone synthesis by improving mitochondrial function and reducing oxidative stress in Leydig cells.Poultry science · 2026Article
- Environmental light deprivation disrupts Leydig cell maturation and male reproductive development in rats.Scientific reports · 2025Article
- Circadian disruption impairs Leydig cell maturation and reproductive development in male rats.Reproductive biology and endocrinology : RB&E · 2025Article
- Adaptation under constant light or dark: a challenge to the pineal.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2025Article
- Sperm DNA methylation landscape and its links to male fertility in a non-model teleost using EM-seq.Heredity · 2025Article
- In vitro effect of hCG on cryptorchid patients' gubernacular cells: a predictive model for adjuvant personalized therapy.Cell communication and signaling : CCS · 2025Article
- Mitochondrial Dynamics as Potential Modulators of Hormonal Therapy Effectiveness in Males.Biology · 2023Review
- Testicular macrophages are recruited during a narrow fetal time window and promote organ-specific developmental functions.Nature communications · 2023Article
- The cost of the circadian desynchrony on the Leydig cell function.Scientific reports · 2022Article
- Article
- From subjective to objective: A pilot study on testicular radiomics analysis as a measure of gonadal function.Andrology · 2022Observational
- "Seminal testosterone", rising viewpoint of local spermatogenesis in nonobstructive azoospermia: One center long-term bidirectional cohort study.Frontiers in endocrinology · 2022Article
- Mitochondria: From Physiology to Pathology.Life (Basel, Switzerland) · 2021Article
- Review
- Mitochondrial Dynamics Markers and Related Signaling Molecules Are Important Regulators of Spermatozoa Number and Functionality.International journal of molecular sciences · 2021Article
- Growing Up Under Constant Light: A Challenge to the Endocrine Function of the Leydig Cells.Frontiers in endocrinology · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Knowledge about the relationship between steroidogenesis and the regulation of the mitochondrial bioenergetics and dynamics, in steroidogenic cells, is not completely elucidated. Here we employed in vivo and ex vivo experimental models to analyze mitochondrial physiology in Leydig cells depending on the different LH-cAMP environments. Activation of LH-receptor in rat Leydig cells ex and in vivo triggered cAMP, increased oxygen consumption, mitoenergetic and steroidogenic activities. Increased mitoenergetic activity i.e., ATP production is achieved through augmented glycolytic ATP production and a small part of oxidative phosphorylation (OXPHOS). Transcription of major genes responsible for mitochondrial dynamics was upregulated for
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Registered trials
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