ArticleNeuroImage. Clinical2020
Biotypes of major depressive disorder: Neuroimaging evidence from resting-state default mode network patterns.
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Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers, 1 of them a synthesis that pooled it.
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Who cites it
54 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The habenula in mood disorders: A systematic review of human studies.Molecular psychiatry · 2025Pooled it
- Effects of 12-week escitalopram treatment on resting-state functional connectivity of large-scale brain networks in major depressive disorder.Human brain mapping · 2023Trial
- Connectomic signatures advance the understandings of transdiagnostic heterogeneity in psychosis.Communications medicine · 2026Review
- Stable depression subtypes identified using functional connectome normative deviation models and their response to rTMS.Molecular psychiatry · 2026Article
- HDGNN-Mamba2: Mamba-Based Spatiotemporal Heterogeneous Dynamic Graph Neural Network for Major Depressive Disorder Classification.Brain sciences · 2026Article
- Unveiling the enigma of anxiety disorders and depression: from pathogenesis to treatment.Science China. Life sciences · 2026Review
- Artificial intelligence and pediatric imaging data: ethical strategies for learning and collaboration.Pediatric radiology · 2026Review
- Distinct Biotypes of Visual Perception in Major Depressive Disorder.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Connectome-based growth models reveal individual heterogeneity and neurophysiological subtypes of subthreshold depression.Molecular psychiatry · 2026Article
- Developing Clinically Interpretable Neuroimaging Biotypes in Psychiatry.Biological psychiatry · 2026Review
- Multimodal Representation Learning for Parsing Biological Heterogeneity in Psychiatric Neuroimaging.Biological psychiatry · 2026Review
- Multimodal MRI and machine learning for identifying depression in cerebral small vessel disease: a multicenter study.BMC medical imaging · 2026Article
- Diagnostic utility of biomarkers in progressive supranuclear palsy: toward a biotyping framework.Journal of neurology · 2025Review
- Heterogeneity of brain functional connectivity, transcriptome, and neurotransmitter profiles in major depressive disorder.Psychological medicine · 2025Article
- Similarities and differences of regional brain activity between first-episode drug-naïve anxious and nonanxious MDD patients.BMC psychiatry · 2025Article
- Gender differences in the interactions and inferred causal relationships between risk factors and gaming disorder: a network and structural equation modeling approach.European archives of psychiatry and clinical neuroscience · 2025Article
- Latent Profile Analysis of Childhood Maltreatment and Neural Markers in Depression.JAMA network open · 2025Article
- Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity.BMC psychiatry · 2025Article
- Neuroimaging-based variability in subtyping biomarkers for psychiatric heterogeneity.Molecular psychiatry · 2025Article
- Major depressive disorder on a neuromorphic continuum.Nature communications · 2025Article
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Authors and funding
67 authors.
Sugai LiangMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Wei DengMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Xiaojing LiMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Andrew J GreenshawDepartment of Psychiatry, University of Alberta, Edmonton T6G 2B7, AB, Canada.
Qiang WangMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Mingli LiMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Xiaohong MaMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Tong-Jian BaiAnhui Medical University, Hefei 230032, Anhui, China.
Qi-Jing BoBeijing Anding Hospital, Capital Medical University, Beijing 100069, China.
Jun CaoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Guan-Mao ChenThe First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China.
Wei ChenSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
Chang ChengThe Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Yu-Qi ChengFirst Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China.
Xi-Long CuiThe Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Jia DuanDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China.
Yi-Ru FangDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Qi-Yong GongHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China; Psychoradiology Research Unit of Chinese Academy of Medical Sciences, West China Hospital of Sichuan University, Chengdu 610040, Sichuan, China.
Wen-Bin GuoThe Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Zheng-Hua HouDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China.
Lan HuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Li KuangDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Feng LiBeijing Anding Hospital, Capital Medical University, Beijing 100069, China.
Kai-Ming LiHuaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China.
Yan-Song LiuDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China.
Zhe-Ning LiuThe Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Yi-Cheng LongFaculty of Psychology, Southwest University, Chongqing 400715, China.
Qing-Hua LuoDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Hua-Qing MengDepartment of Clinical Psychology, Suzhou Psychiatric Hospital, The Affiliated Guangji Hospital of Soochow University, Suzhou 215031, Jiangsu, China.
Dai-Hui PengDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Hai-Tang QiuDepartment of Psychiatry, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Jiang QiuFaculty of Psychology, Southwest University, Chongqing 400715, China.
Yue-Di ShenDepartment of Diagnostics, Affiliated Hospital, Hangzhou Normal University Medical School, Hangzhou 311121, Zhejiang, China.
Yu-Shu ShiDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Tian-Mei SiNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
Chuan-Yue WangBeijing Anding Hospital, Capital Medical University, Beijing 100069, China.
Fei WangDepartment of Psychiatry, First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning, China.
Kai WangBeijing Anding Hospital, Capital Medical University, Beijing 100069, China.
Li WangNational Clinical Research Center for Mental Disorders (Peking University Sixth Hospital) & Key Laboratory of Mental Health, Ministry of Health (Peking University), Beijing 100191, China.
Xiang WangSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
Ying WangThe First Affiliated Hospital of Jinan University, Guangzhou 510630, Guangdong, China.
Xiao-Ping WuXi'an Central Hospital, Xi'an 710032, Shaanxi, China.
Xin-Ran WuFaculty of Psychology, Southwest University, Chongqing 400715, China.
Chun-Ming XieDepartment of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China.
Guang-Rong XieThe Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Hai-Yan XieDepartment of Psychiatry, The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Peng XieInstitute of Neuroscience, Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurobiology, Chongqing 400016, China; Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China.
Xiu-Feng XuFirst Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China.
Hong YangDepartment of Radiology, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310058, Zhejiang, China.
Jian YangThe First Affiliated Hospital of Xi'an Jiaotong University, 710049 Shaanxi, China.
Hua YuMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Jia-Shu YaoSir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310058, Zhejiang, China.
Shu-Qiao YaoThe Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Ying-Ying YinDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China.
Yong-Gui YuanDepartment of Psychosomatics and Psychiatry, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210096, Jiangsu, China.
Yu-Feng ZangCenter for Cognition and Brain Disorders, Institutes of Psychological Sciences, Hangzhou Normal University, Hangzhou 311121, Zhejiang, China; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments, Hangzhou 311121, Zhejiang, China.
Ai-Xia ZhangThe First Affiliated Hospital of Xi'an Jiaotong University, 710049 Shaanxi, China.
Hong ZhangXi'an Central Hospital, Xi'an 710032, Shaanxi, China.
Ke-Rang ZhangFirst Hospital of Shanxi Medical University, Taiyuan 030607, Shanxi, China.
Zhi-Jun ZhangDepartment of Neurology, Affiliated Zhongda Hospital of Southeast University, Nanjing 210096, Jiangsu, China.
Jing-Ping ZhaoThe Institute of Mental Health, Second Xiangya Hospital of Central South University, Changsha 410083, Hunan, China.
Ru-Bai ZhouDepartment of Psychiatry, Shanghai Jiao Tong University School of Medicine, Shanghai 200240, China.
Yi-Ting ZhouMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China.
Chao-Jie ZouFirst Affiliated Hospital of Kunming Medical University, Kunming 650211, Yunnan, China.
Xi-Nian ZuoCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China.
Chao-Gan YanCAS Key Laboratory of Behavioral Science, Institute of Psychology, Beijing 100101, China; Department of Psychology, University of Chinese Academy of Sciences, Beijing 100101, China; Magnetic Resonance Imaging Research Center and Research Center for Lifespan Development of Mind and Brain (CLIMB), Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China. Electronic address: yancg@psych.ac.cn.
Tao LiMental Health Center & Psychiatric Laboratory, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; West China Brain Research Centre, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China. Electronic address: litaohx@scu.edu.cn.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMajor depressive disorder (MDD) is heterogeneous disorder associated with aberrant functional connectivity within the default mode network (DMN). This study focused on data-driven identification and validation of potential DMN-pattern-based MDD subtypes to parse heterogeneity of the disorder.
methodsThe sample comprised 1397 participants including 690 patients with MDD and 707 healthy controls (HC) registered from multiple sites based on the REST-meta-MDD Project in China. Baseline resting-state functional magnetic resonance imaging (rs-fMRI) data was recorded for each participant. Discriminative features were selected from DMN between patients and HC. Patient subgroups were defined by K-means and principle component analysis in the multi-site datasets and validated in an independent single-site dataset. Statistical significance of resultant clustering were confirmed. Demographic and clinical variables were compared between identified patient subgroups.
resultsTwo MDD subgroups with differing functional connectivity profiles of DMN were identified in the multi-site datasets, and relatively stable in different validation samples. The predominant dysfunctional connectivity profiles were detected among superior frontal cortex, ventral medial prefrontal cortex, posterior cingulate cortex and precuneus, whereas one subgroup exhibited increases of connectivity (hyperDMN MDD) and another subgroup showed decreases of connectivity (hypoDMN MDD). The hyperDMN subgroup in the discovery dataset had age-related severity of depressive symptoms. Patient subgroups had comparable demographic and clinical symptom variables.
conclusionsFindings suggest the existence of two neural subtypes of MDD associated with different dysfunctional DMN connectivity patterns, which may provide useful evidence for parsing heterogeneity of depression and be valuable to inform the search for personalized treatment strategies.
Indexed as
Major Depressive DisorderBrainBrain MappingChinaDefault Mode NetworkHumansMagnetic Resonance ImagingNeural PathwaysNeuroimagingBiotypesDefault mode networkMachine learningMajor depressive disorderResting-state fMRI
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