ArticleNeuroImage. Clinical2020
Brain networks associated with anticipatory postural adjustments in Parkinson's disease patients with freezing of gait.
Article in NeuroImage. Clinical, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- A Pragmatic Review on Spinal Cord Stimulation Therapy for Parkinson's Disease Gait Related Disorders: Gaps and Controversies.Movement disorders clinical practice · 2024Pooled it
- Spinal cord stimulation therapy for gait impairment in Parkinson's disease: a double-blinded, randomised feasibility trial with an open extension.Nature communications · 2026Trial
- Brain modulation after exergaming training in advanced forms of Parkinson's disease: a randomized controlled study.Journal of neuroengineering and rehabilitation · 2024Trial
- Freezing of Gait: A Tribute to Nir Giladi.The European journal of neuroscience · 2026Article
- Effects of galvanic vestibular stimulation on motor control in patients with Parkinson's disease: study protocol.Arquivos de neuro-psiquiatria · 2026Article
- Motor planning stage of gait initiation: effects of aging, Parkinson's disease, and associations with cognitive function.Experimental brain research · 2025Article
- Rehabilitation Response in Tremor- and Non-Tremor-Dominant Parkinson Disease: A Task-fMRI Study.Brain and behavior · 2024Article
- High-frequency rTMS over bilateral primary motor cortex improves freezing of gait and emotion regulation in patients with Parkinson's disease: a randomized controlled trial.Frontiers in aging neuroscience · 2024Article
- Impaired structural and reserved functional topological organizations of brain networks in Parkinson's disease with freezing of gait.Quantitative imaging in medicine and surgery · 2023Article
- Human Standing Posture Motion Evaluation by the Visual Simulation of Multi-Directional Sea-Waves.Sensors (Basel, Switzerland) · 2022Article
- A Novel Viewpoint on the Anticipatory Postural Adjustments During Gait Initiation.Frontiers in human neuroscience · 2021Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Specific impairments of anticipatory postural adjustment (APA) during step initiation have been reported in patients with Parkinson's disease (PD) and freezing of gait (FoG). Although APA disruption has been associated with FoG, there is scarce knowledge about its neural correlates. We sought to better understand the neural networks involved with APA in patients with FoG by assessing the level of hemodynamic response of specific brain regions and the functional connectivity during the leg lifting task. In the current investigation, APAs of patients with PD, with and without (nFoG) freezing were assessed during a leg lifting task in an event-related, functional magnetic resonance imaging (er-fMRI) protocol. Results identified a high hemodynamic response in the right anterior insula (AI) and supplementary motor area (SMA) in the FoG group when an APA was required. The nFoG had stronger connectivity between the right and left insulae than the FoG group. The strength of this connectivity was negatively correlated with the severity of FoG. Both groups showed different brain network organizations comprising the SMA and the bilateral AI. The SMA was found to be a hub in patients with FoG when an APA was required for the task. Our findings suggest that both groups used compensatory mechanism comprising the insulae during APA. Neither group used the entire network comprised of the insulae and SMA to accomplish the task. The FoG group relied more on SMA as a hub than as part of a broader network to exchange information during the APA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.