ArticleInternational journal of surgery case reports2020
Fournier's gangrene under SGLT-2 inhibitor therapy: A literature review and case report.
Article in International journal of surgery case reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- The impact of sodium-glucose cotransporter-2 inhibitors on the incidence, therapy, and outcomes of fournier gangrene: insights from a systematic review of case reports.Systematic reviews · 2025Pooled it
- Association between SGLT2 inhibitor use and Fournier's gangrene after genital or perineal surgery: a retrospective cohort study.World journal of urology · 2026Article
- Cutaneous Adverse Drug Reactions Associated with SGLT2 Inhibitors.Journal of clinical medicine · 2024Review
- Skin-Related Adverse Reactions Induced by Oral Antidiabetic Drugs-A Review of Literature and Case Reports.Pharmaceuticals (Basel, Switzerland) · 2024Review
- Fournier's Gangrene as an Adverse Event Following Treatment with Sodium Glucose Cotransporter 2 Inhibitors.Medicina (Kaunas, Lithuania) · 2024Article
- Case literature analysis of Fournier's gangrene caused by sodium-glucose protein-2 inhibitors.Frontiers in medicine · 2024Article
- Insight on Infections in Diabetic Setting.Biomedicines · 2023Review
- Bibliometric insights in fournier's gangrene: Research landscapes, turning points, and global trends.Frontiers in surgery · 2023Review
- Review
- Management of Fournier's gangrene during the Covid-19 pandemic era: make a virtue out of necessity.Basic and clinical andrology · 2022Article
- Fournier's Gangrene under Sodium-Glucose Cotransporter-2 Inhibitors Therapy in Gynecological Patients.International journal of environmental research and public health · 2022Review
- A case of Fournier's gangrene following a large-volume hydrocelectomy in a diabetic patient managed with SGLT-2 inhibitor therapy.Urology case reports · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFournier's gangrene is a rare, life-threatening necrotizing infection of the perineum. In 2018, the U.S. Food and Drug Administration (FDA) issued a warning regarding a possible connection between Fournier's gangrene and new oral anti-diabetic drugs called SGLT-2 inhibitors. There are only a few published case reports of Fournier's gangrene in patients treated with SGLT-2 inhibitors and a total of 55 patients reported by the FDA to date. PRESENTATION OF CASE: We report a case of Fournier's gangrene in a patient with multiple risk factors, including diabetes type 2, smoking, obesity and immunosuppression. DISCUSSION: Further studies are needed to determine whether or not it is the SGLT-2 inhibitor itself that increases the risk of Fournier's gangrene, or the fact that the patients receiving this kind of drug is a subgroup of patients with multiple risk factors.
conclusionNew oral anti-diabetic drugs, SGLT-2 inhibitors, may be associated with Fournier's gangrene. Surgeons should become suspicious when patients with diabetes present with perineal symptoms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.