Evidence map›Paper›PMID 33395778›Full record

SynthesisDiabetes & metabolic syndrome

The Effect of Metformin Consumption on Mortality in Hospitalized COVID-19 patients: a systematic review and meta-analysis.

Antonia Anna Lukito, Raymond Pranata, Joshua Henrina, Michael Anthonius Lim, Sherly Lawrensia, Ketut Suastika

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Diabetes & metabolic syndrome. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  4. Endotheliopathy marked by high von Willebrand factor (vWF) antigen in COVID-19 is associated with poor outcome: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2022
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  11. Active prescription of low-dose aspirin during or prior to hospitalization and mortality in COVID-19: A systematic review and meta-analysis of adjusted effect estimates.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2021
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1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Antonia Anna LukitoDepartment of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia. Electronic address: Antonia.lukito@uph.edu.
Raymond PranataFaculty of Medicine, Universitas Pelita Harapan, Tangerang, Indonesia. Electronic address: raymond_pranata@hotmail.com.
Joshua HenrinaRSUD Balaraja, Tangerang, Indonesia. Electronic address: joshuahenrina@gmail.com.
Michael Anthonius LimDepartment of Cardiology and Vascular Medicine, Siloam Hospitals Lippo Village, Tangerang, Indonesia. Electronic address: lim.michael.a@gmail.com.
Sherly LawrensiaKen Saras General Hospital, Semarang, Indonesia. Electronic address: sherlylawrensia@gmail.com.
Ketut SuastikaHead, Division of Endocrinology and Metabolism Department of Internal Medicine, Faculty of Medicine, Udayana University. Denpasar, Bali, Indonesia Denpasar, Bali, Indonesia. Electronic address: ksuas@unud.ac.id.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

aimsDiabetes is one of the most common comorbidities, and it is associated with poorer outcomes in patients with coronavirus disease 2019 (COVID-19). Preliminary findings showed that mortality was reduced in those who consume metformin compared to those who did not, and given its low cost and widespread availability; metformin is an attractive and potential agent to mitigate excessive risk in diabetic populations.

methodsSeveral medical databases (Pubmed, EuropePMC, EBSCOhost, Proquest, Cochrane library) and two health-science preprint servers (preprint.org and Medrxiv) were systematically searched for relevant literature.

resultsNine studies with 10,233 subjects were included in the qualitative and quantitative synthesis. Meta-analysis showed that metformin is associated with lower mortality in pooled non-adjusted model (OR 0.45 [0.25, 0.81], p = 0.008; I

conclusionThe analysis showed that metformin consumption was associated with lower mortality. Randomized controlled trials are needed to confirm this finding.

Indexed as

COVID-19 Drug TreatmentCOVID-19Hospital MortalityHumansHypoglycemic AgentsMetforminRetrospective StudiesHypoglycemic AgentsMetforminCOVID-19Diabetes melitusMetforminMortalitySARS-CoV-2

Identifiers

PMID33395778
PMCPMC7657016

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.