Evidence map›Paper›PMID 33395550›Full record

ReviewAnnual review of biophysics2021

Biophysics of Chromatin Remodeling.

Ilana M Nodelman, Gregory D Bowman

Open access · bronzeAbstract readReview
In one paragraph

Review in Annual review of biophysics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed
3.8field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 62 citations in OpenAlex.

  1. Article
  2. Tuning epigenetics to enhance cancer virotherapy.Acta pharmaceutica Sinica. B · 2026
    Review
  3. Review
  4. Article
  5. Review
  6. Human mutation · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Article
  13. Mechanistic insights into INO80-type chromatin remodelers.Current opinion in structural biology · 2025
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. How the chromatin landscape influences nuclear morphology.Frontiers in cell and developmental biology · 2025
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Ilana M NodelmanT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA; email: gdbowman@jhu.edu.
Gregory D BowmanT.C. Jenkins Department of Biophysics, Johns Hopkins University, Baltimore, Maryland 21218, USA; email: gdbowman@jhu.edu.
Johns Hopkins University · US

Funding

Structural and Functional Characterization of the Chd1 Chromatin RemodelerR01GM084192 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI BOWMAN, GREGORY DEAN · 2008 to 2024
$6.3M
Acquisition of GE Typhoon FLA9500 Variable Mode ImagerS10OD021567 · OD · JOHNS HOPKINS UNIVERSITY · PI MCCAFFERY, J. MICHAEL · 2017 to 2017
$147k
NIGMS NIH HHS R01 GM084192NIH HHS S10 OD021567
6 · The paper itself

Abstract

As primary carriers of epigenetic information and gatekeepers of genomic DNA, nucleosomes are essential for proper growth and development of all eukaryotic cells. Although they are intrinsically dynamic, nucleosomes are actively reorganized by ATP-dependent chromatin remodelers. Chromatin remodelers contain helicase-like ATPase motor domains that can translocate along DNA, and a long-standing question in the field is how this activity is used to reposition or slide nucleosomes. In addition to ratcheting along DNA like their helicase ancestors, remodeler ATPases appear to dictate specific alternating geometries of the DNA duplex, providing an unexpected means for moving DNA past the histone core. Emerging evidence supports twist-based mechanisms for ATP-driven repositioning of nucleosomes along DNA. In this review, we discuss core experimental findings and ideas that have shaped the view of how nucleosome sliding may be achieved.

Indexed as

Chromatin Assembly and DisassemblyAdenosine TriphosphatasesBiophysical PhenomenaDNA-Binding ProteinsNucleosomesAdenosine TriphosphatasesDNA-Binding ProteinsNucleosomesbulge/loop propagationhistonenucleosomeSF2 superfamilySnf2-type ATPase motortwist defect

Identifiers

PMID33395550
PMCPMC8428145
OpenAlexW3120854544

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.