ArticlePloS one2021
Seroprevalence and risk factors associated with exposure to Leishmania infantum in dogs, in an endemic Mediterranean region.
Article in PloS one, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.
- Risk and protective factors for canine visceral leishmaniasis in the Americas: a systematic review update with meta-analysis.Parasites & vectors · 2026Pooled it
- Canine Leishmaniosis in Italy: Geospatial Trends and Incidence, a Shift in Epidemiological Approach.Zoonoses and public health · 2026Article
- Seroprevalence and Factors Associated with Canine Leishmaniasis in Baringo County, Kenya: Implications for an Integrated One Health Surveillance.Veterinary sciences · 2026Article
- Community Drivers ofTropical medicine and infectious disease · 2026Article
- Leishmania infantum infection in Phlebotomus perniciosus and Phlebotomus perfiliewi (Diptera, Psychodidae) and their abundance in central Italy.Parasites & vectors · 2026Article
- Canine Leishmaniosis in Liguria, Northwest Italy: A Nine-Year Retrospective Study in a Historically Endemic Area.Animals : an open access journal from MDPI · 2026Article
- Zoonotic leishmaniasis in China: Current status and challenges to elimination.PLoS neglected tropical diseases · 2026Review
- Dogs as sentinel hosts for sand-fly-borne infections in the Mediterranean Basin: a multinational serological survey.Parasites & vectors · 2026Article
- The frequency, risk factors and spatial distribution associated with having a diagnosis of leishmaniosis in dogs in the UK in 2019.PloS one · 2026Article
- Seroprevalence, clinical investigation, and risk factors associated withJournal of parasitic diseases : official organ of the Indian Society for Parasitology · 2025Article
- Molecular Prevalence ofPathogens (Basel, Switzerland) · 2025Article
- Characterisation and evaluation of predisposing factors for the development of xanthinuria in dogs with leishmaniosis under allopurinol therapy.Parasites & vectors · 2025Article
- Molecular characterization ofOpen veterinary journal · 2025Article
- Efficacy of meglumine antimoniate treatment on boxerFrontiers in veterinary science · 2025Article
- Case Report: Disseminated leishmaniasis and rheumatoid arthritis: navigating a clinical conundrum.Frontiers in immunology · 2025Article
- Development of a Simple IFN-γ Release Whole Blood Assay for the Assessment ofAnimals : an open access journal from MDPI · 2024Article
- Distribution of and Relationships between Epidemiological and Clinicopathological Parameters in Canine Leishmaniosis: A Retrospective Study of 15 Years (2009-2023).Pathogens (Basel, Switzerland) · 2024Article
- Effect of Breed on Hematological and Biochemical Parameters of Apparently Healthy Dogs Infected with Zoonotic Pathogens Endemic to the Mediterranean Basin.Animals : an open access journal from MDPI · 2024Article
- Serological survey of Leishmania infantum in apparently healthy dogs in different areas of Spain.Veterinary medicine and science · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Canine leishmaniasis (CanL) is a zoonotic parasitic disease caused by Leishmania infantum in the Mediterranean area and transmitted by phlebotomine sand fly vectors. The domestic dog is the main reservoir host. The aim of this study was to assess the influence of different individual, environmental and spatial risk factors on the dog exposure to L. infantum and to estimate the seroprevalence among owned and kennel dogs, in the Lazio region (central Italy), where canine leishmaniasis is endemic. In the period 2010-2014, 13,292 sera from kennel and owned dogs were collected by official and private veterinarians. The presence of anti-Leishmania IgG was analysed by indirect fluorescent antibody test (IFAT), using a 1:80 titre cut-off. At the univariable analysis, CanL seropositivity was associated with sex, size, breed, coat length, living with other dogs and forest/semi-natural land cover. At the multivariable analysis, age, ownership and attitude were confirmed as risk factors, being more than 2 years old, owned, and hunting dogs at higher risk. Being a Maremma sheepdog was a protective factor. A true overall seroprevalence of 6.7% (95% CI: 6.2-7.2) was estimated in the whole population while 7.3% (95% CI: 6.8-7.8) was estimated in kennel dogs and 74.3% (95% CI: 70.8-77.6) in owned dogs. The role of kennels as a key component for CanL active and passive surveillance was also highlighted. This study confirmed the endemicity of CanL in the Lazio region and focused some factors that can influence the seropositivity of dogs in a Mediterranean region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.