Evidence map›Paper›PMID 33394741›Full record

ReviewCurrent opinion in pediatrics2021

Acute severe respiratory syndrome coronavirus-2 treatment overview for pediatrics.

Mark E Murphy, Gwendolyn Clay, Lara Danziger-Isakov, Grant Schulert, Grant C Paulsen

Abstract readReview
In one paragraph

Review in Current opinion in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. [COVID-19 pandemic. What have we learned?]Anales de pediatria (Barcelona, Spain : 2003) · 2021
    Article
  2. COVID-19 pandemic. What have we learned?Anales de pediatria · 2021
    Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mark E MurphyDivision of Infectious Diseases.
Gwendolyn ClayDivision of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center.
Lara Danziger-IsakovDivision of Infectious Diseases.
Grant SchulertDivision of Rheumatology, Department of Pediatrics, Cincinnati Children's Hospital Medical Center.
Grant C PaulsenDivision of Infectious Diseases.

Funding

T32 Cincinnati Pediatric Clinical Pharmacology Training ProgramT32HD069054 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI TRACY A GLAUSER, Sonya C Tang Girdwood · 2011 to 2026
$3.0M
CINCINNATI TRAINING PROGRAM IN PEDIATRIC RHEUMATOLOGYRESEARCHT32AR069512 · NIAMS · CINCINNATI CHILDRENS HOSP MED CTR · PI ALEXEI A GROM, Grant Sanford Schulert · 2016 to 2026
$1.6M
NIAMS NIH HHS T32 AR069512NICHD NIH HHS T32 HD069054
6 · The paper itself

Abstract

purpose of reviewThe novel severe respiratory syndrome coronavirus-2 (SARS-CoV-2) virus has caused a world-wide pandemic with devastating effects. Fortunately, most children display only mild-to-moderate symptoms, but there are a subset that will have severe symptoms warranting treatment. This review evaluates the current evidence for antiviral and anti-inflammatory treatment of acute SARS-COV-2 infections, including coronavirus disease 2019 in pediatrics. RECENT

findingsTreatment recommendations continue to evolve with emerging results from clinical trials. Initial therapies were tailored to repurposed medications, and have now transitioned toward more specific antiviral therapy. In addition to specific antiviral therapy, there is also support to modulate the immune system and reduce inflammatory damage seen in coronavirus disease 2019. Much of the data result from adult studies with subsequent extrapolation to pediatrics. SUMMARY: Recommended therapy will continue to adapt as results return from clinical trials. A continued commitment from the National Institutes of Health and research community to assist in determining optimal therapies for pediatric patients is essential. Until then, most recommendations will likely be informed from the results seen in adult populations.

Indexed as

COVID-19 Drug TreatmentPediatricsAdultAnti-Inflammatory AgentsAntiviral AgentsChildHumansUnited StatesAnti-Inflammatory AgentsAntiviral Agents

Identifiers

PMID33394741
PMCPMC7861135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.