ReviewEnvironmental science and pollution research international2021
Airway hyperresponsiveness development and the toxicity of PM2.5.
Review in Environmental science and pollution research international, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Genetic and environmental risk factors of asthma: a narrative review.Frontiers in immunology · 2026Pooled it
- Long-Term Exposure to Fine Particulate Matter and the Risk of Chronic Liver Diseases: A Meta-Analysis of Observational Studies.International journal of environmental research and public health · 2022Pooled it
- Article
- Obesity, Air Pollution, and Epigenetic Modifications as Risk Factors for Asthma Phenotypes.International journal of molecular sciences · 2026Review
- Associations Between Air Pollution and Hospitalization of Patients with Chronic Obstructive Pulmonary Disease in Kashi, China: A Time-Stratified Case-Crossover Study.International journal of chronic obstructive pulmonary disease · 2026Article
- Genetic susceptibility to PMFrontiers in immunology · 2026Article
- Evolving relationships between air pollution attenuation and AECOPD hospitalizations during a stringent control period in Shijiazhuang, China, 2017-2024.Frontiers in public health · 2026Article
- Looking through the particles: a narrative review of air pollution and lung cancer.Journal of thoracic disease · 2025Review
- Differential Effects of Wildfire Smoke Fine Particulate Matter Exposure on Respiratory Disease Emergency Department Visits in the Western United States.American journal of respiratory and critical care medicine · 2025Article
- Early Origins of Asthma and Allergies: Clues From Studies in China.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Review
- A Companion Robot for Children With Asthma: Descriptive Development and Feasibility Pilot Study.JMIR pediatrics and parenting · 2025Article
- Long-term exposure to ambient air pollutant and acute exacerbations of chronic obstructive pulmonary disease: a retrospective cohort study in Xinjiang, China.Frontiers in public health · 2025Article
- Changes in the "U-Shaped" Distribution of Airway Hyperresponsiveness and Characterization of Inflammatory Phenotypes in Different Age Groups.Journal of asthma and allergy · 2025Article
- Notch Signaling Pathway Interfering as a Possible Asthma Treatment: A Narrative Review.Journal of asthma and allergy · 2025Review
- Particulate matter-induced epigenetic modifications and lung complications.European respiratory review : an official journal of the European Respiratory Society · 2024Review
- The Most Common Environmental Risk Factors for Equine Asthma-A Narrative Review.Animals : an open access journal from MDPI · 2024Review
- Impact of Respiratory Dust on Health: A Comparison Based on the Toxicity of PM2.5, Silica, and Nanosilica.International journal of molecular sciences · 2024Review
- Effect of air pollution on asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2024Review
- Pathogenesis of PMEpigenomes · 2024Review
- The Effects of Turmeric and Mangosteen Pericarp Ethanol Extract on Eosinophil Count, TNF-α and TGF-β1 Gene Expression in Asthmatic Rat Model.Journal of experimental pharmacology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Airway hyperresponsiveness (AHR) is characterized by excessive bronchoconstriction in response to nonspecific stimuli, thereby leading to airway stenosis and increased airway resistance. AHR is recognized as a key characteristic of asthma and is associated with significant morbidity. At present, many studies on the molecular mechanisms of AHR have mainly focused on the imbalance in Th1/Th2 cell function and the abnormal contraction of airway smooth muscle cells. However, the specific mechanisms of AHR remain unclear and need to be systematically elaborated. In addition, the effect of air pollution on the respiratory system has become a worldwide concern. To date, numerous studies have indicated that certain concentrations of fine particulate matter (PM2.5) can increase airway responsiveness and induce acute exacerbation of asthma. Of note, the concentration of PM2.5 does correlate with the degree of AHR. Numerous studies exploring the toxicity of PM2.5 have mainly focused on the inflammatory response, oxidative stress, genotoxicity, apoptosis, autophagy, and so on. However, there have been few reviews systematically elaborating the molecular mechanisms by which PM2.5 induces AHR. The present review separately sheds light on the underlying molecular mechanisms of AHR and PM2.5-induced AHR.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.