Evidence map›Paper›PMID 33394379›Full record

ArticleHead and neck pathology2021

A Poorly Differentiated Non-keratinizing Sinonasal Squamous Cell Carcinoma with a Novel ETV6-TNFRSF8 Fusion Gene.

Justin Bubola, Christina M MacMillan, Ilan Weinreb, Ian Witterick, David Swanson, Lei Zhang, Cristina R Antonescu, Brendan C Dickson

Open access · greenAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Head and neck pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Justin BubolaDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Christina M MacMillanDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Ilan WeinrebDepartment of Pathology, University Health Network, Toronto, ON, Canada.
Ian WitterickDepartment of Otolaryngology Head and Neck Surgery, Department of Surgical Oncology, University Health Network, Toronto, ON, Canada.
David SwansonDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada.
Lei ZhangDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Cristina R AntonescuDepartment of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
Brendan C DicksonDepartment of Pathology and Laboratory Medicine, Mount Sinai Hospital, Toronto, ON, Canada. Brendan.Dickson@sinaihealth.ca.ORCID http://orcid.org/0000-0003-2269-6216
Mount Sinai Hospital · CAMemorial Sloan Kettering Cancer Center · USUniversity Health Network · CA

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

Squamous cell carcinoma of the sinonasal tract is relatively rare and morphologically and genetically heterogeneous. We report the case of an adult male with a left sphenoid sinus mass. A biopsy revealed an undifferentiated carcinoma composed of sheets of epithelioid cells lacking keratinization and glandular formation. The tumor was associated with a prominent lymphoplasmacytic inflammatory infiltrate. Immunohistochemical staining demonstrated diffuse expression of pankeratin and p63; it was negative for p16. In addition, EBER was also negative. Morphologically the findings raised the possibility of non-keratinizing squamous cell carcinoma. RNA sequencing was undertaken to exclude the possibility of NUT carcinoma; interestingly, this revealed a novel ETV6-TNFRSF8 fusion transcript, which was independently confirmed by fluorescence in situ hybridization. The current case is illustrative because it broadens our understanding of the molecular pathogenesis of non-keratinizing squamous cell carcinoma and adds to the diversity of ETV6-rearranged malignancies.

Indexed as

Ki-1 AntigenAgedBiomarkers, TumorCarcinoma, Squamous CellCombined Modality TherapyDiagnosis, DifferentialETS Translocation Variant 6 ProteinHumansMagnetic Resonance ImagingMaleParanasal Sinus NeoplasmsProto-Oncogene Proteins c-etsRepressor ProteinsTomography, X-Ray ComputedBiomarkers, TumorETS Translocation Variant 6 ProteinKi-1 AntigenProto-Oncogene Proteins c-etsRepressor ProteinsETV6Sinonasal carcinomaTNFRSF8

Identifiers

PMID33394379
PMCPMC8633219
OpenAlexW3120388427

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.