Evidence map›Paper›PMID 33394282›Full record

ArticleInternational urology and nephrology2021

Risk factors for delayed graft function and their impact on graft outcomes in live donor kidney transplantation.

Shivashankar Damodaran, Brenna Bullock, Obi Ekwenna, Mehdi Nayebpour, Naoru Koizumi, Puneet Sindhwani, Jorge Ortiz

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In one paragraph

Article in International urology and nephrology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Shivashankar DamodaranDepartment of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA. Shivashankar.damodaran@utoledo.edu.ORCID http://orcid.org/0000-0001-6392-2553
Brenna BullockCollege of Medicine and Life Sciences, University of Toledo, 3000, Arlington Ave, Toledo, OH, 43614, USA.
Obi EkwennaDepartment of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA.
Mehdi NayebpourSchar School of Policy and Government, George Mason University, Arlington Campus, Van Metre Hall 520, 3351 N. Fairfax Dr. MS#3B1, Arlington, VA, 22201, USA.
Naoru KoizumiSchar School of Policy and Government, George Mason University, Arlington Campus, Van Metre Hall 520, 3351 N. Fairfax Dr. MS#3B1, Arlington, VA, 22201, USA.
Puneet SindhwaniDepartment of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA.
Jorge OrtizDepartment of Urology and Renal Transplant, University of Toledo, 3000, Arlington Ave, MS1091, Toledo, OH, 43614, USA.
University of Toledo · USGeorge Mason University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDelayed graft function (DGF) is a manifestation of acute kidney injury uniquely framed within the transplant process and a predictor of poor long-term graft function1. It is less common in the setting of living donor (LD) kidney transplantation. However, the detrimental impact of DGF on graft survival is more pronounced in LD2. PURPOSE: To study the effects of DGF in the setting of LD kidney transplantation.

methodsWe performed a retrospective analysis of LD kidney transplantations performed between 2010 and 2018 in the UNOS/OPTN database for DGF and its effect on graft survival.

resultsA total of 42,736 LD recipients were identified, of whom 1115 (2.6%) developed DGF. Recipient dialysis status, male gender, diabetes, end-stage renal disease, donor age, right donor nephrectomy, panel reactive antibodies, HLA mismatch, and cold ischemia time were independent predictors of DGF. Three-year graft survival in patients with and without DGF was 89% and 95%, respectively. DGF was the greatest predictor of graft failure at three years (hazard ratio = 1.766, 95% CI: 1.514-2.059, P = 0.001) and was associated with higher rates of rejection (9% vs. 6.28%, P = 0.0003). Among patients with DGF, the graft survival rates with and without rejection were not different.

conclusionDGF is a major determinant of poor graft functional outcomes, independent of rejection.

Indexed as

Kidney TransplantationAdultDelayed Graft FunctionFemaleGraft SurvivalHumansLiving DonorsMaleMiddle AgedRetrospective StudiesRisk FactorsTreatment OutcomeDelayed graft functionGraft rejectionGraft survivalKidney transplantationLiving donors

Identifiers

PMID33394282
OpenAlexW3120034727

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.