Evidence map›Paper›PMID 33394148›Full record

ReviewApplied microbiology and biotechnology2021

Natural bacterial isolates as an inexhaustible source of new bacteriocins.

Jelena Lozo, Ljubisa Topisirovic, Milan Kojic

Abstract readReview
PubMed Publisher
In one paragraph

Review in Applied microbiology and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

  1. Article
  2. Expression of Enterocin A in Saccharomyces cerevisiae.Probiotics and antimicrobial proteins · 2026
    Article
  3. Article
  4. Alicyclobacillin 24: a class III bacteriocin fromFrontiers in microbiology · 2026
    Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Insight into the Probiogenomic Potential ofFoods (Basel, Switzerland) · 2024
    Article
  11. Review
  12. Article
  13. Evaluation of autochthonousFood science and biotechnology · 2024
    Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Jelena LozoFaculty of Biology, University of Belgrade, Belgrade, Serbia. jlozo@bio.bg.ac.rs.ORCID https://orcid.org/0000-0001-9888-5270
Ljubisa TopisirovicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.
Milan KojicInstitute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia.ORCID https://orcid.org/0000-0001-5645-750X

Funding

Ministry of Education, Science and Technological Development of the Republic of Serbia 451-03-68/2020-14/ 200178 and 451-03-68/2020-14/ 200042
6 · The paper itself

Abstract

Microorganisms isolated from various traditionally fermented food products prepared in households without commercial starter cultures are designated as natural isolates. In addition, this term is also used for microorganisms collected from various natural habitats or products (silage, soil, manure, plant and animal material, etc.) that do not contain any commercial starters or bacterial formulations. They are characterized by unique traits that are the result of the selective pressure of environmental conditions, as well as interactions with other organisms. The synthesis of antimicrobial molecules, including bacteriocins, is an evolutionary advantage and an adaptive feature that sets them apart from other microorganisms from a common environment. This review aims to underline the knowledge of bacteriocins produced by natural isolates, with a particular emphasis on the most common location of their genes and operons, plasmids, and the importance of the relationship between the plasmidome and the adaptive potential of the isolate. Applications of bacteriocins, ranging from natural food preservatives to supplements and drugs in pharmacology and medicine, will also be addressed. The latest challenges faced by researchers in isolating new natural isolates with desired characteristics will be discussed, as well as the production of new antimicrobials, nearly one century since the first discovery of colicins in 1925. KEY POINTS: • Natural bacterial isolates harbor unique properties shaped by diverse interactions. • Horizontal gene transfer enables constant engineering of new antimicrobials. • Fermented food products are important source of bacteriocin-producing natural isolates.

Indexed as

BacteriocinsAnimalsAnti-Bacterial AgentsBacteriaFood MicrobiologyFood PreservativesAnti-Bacterial AgentsBacteriocinsFood PreservativesBacteriocinsGenome/metagenome miningHeterologous expression/overexpression of bacteriocinsNatural bacterial isolatesPlasmids

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.