Evidence map›Paper›PMID 33394100›Full record

Trial reportExperimental brain research2021

High intensity aerobic exercise improves information processing and motor performance in individuals with Parkinson's disease.

Anson B Rosenfeldt, Mandy Miller Koop, Hubert H Fernandez, Jay L Alberts

Registry-linked trialAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Experimental brain research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01636297 (The Cyclical Lower-extremity Exercise for Parkinson's Trial), which is not on this map. Cited by 11 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 2 pooled it
1.5field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01636297 nacompletednot on this map

The Cyclical Lower-extremity Exercise for Parkinson's Trial

TypeinterventionalSponsorThe Cleveland ClinicRan2013 to 2017Enrolled100ConditionsParkinson's DiseaseArmsForced exercise, Voluntary exercise
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Neurobiology of exercise in Parkinson's disease.Journal of Parkinson's disease · 2026
    Review
  5. Review
  6. Barefoot walking improves cognitive ability in adolescents.The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology · 2024
    Article
  7. Observational
  8. Article
  9. Article
  10. Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Anson B RosenfeldtDepartment of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.ORCID http://orcid.org/0000-0001-5468-8208
Mandy Miller KoopDepartment of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.
Hubert H FernandezCenter for Neurological Restoration, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA.
Jay L AlbertsDepartment of Biomedical Engineering, Cleveland Clinic, 9500 Euclid Ave, Cleveland, OH, USA. albertj@ccf.org.
Cleveland Clinic · US

Funding

The Cyclical Lower-extremity Exercise for Parkinson's TrialR01NS073717 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI ALBERTS, JAY L. · 2011 to 2023
$4.8M
National Institute of Health R01NS673717NINDS NIH HHS R01 NS073717
6 · The paper itself

Abstract

Parkinson's disease (PD) adversely affects information processing and motor performance. The impact of aerobic exercise on modifying the deleterious effects of PD underlying information and motor control processes is not well established. The primary aim of this project was to determine the effects of an 8-week high intensity exercise intervention on information processing and movement execution in individuals with PD. A secondary aim sought to understand the effects of antiparkinsonian medication relative to exercise on motor control processes. Data were collected at baseline (on- and off-medication) and upon completion of the exercise intervention (off-medication). Information processing and motor execution were evaluated via simple and choice reaction time paradigms (SRT and CRT) performed on a mobile device. Neither exercise nor medication impacted information processing or movement execution under the SRT paradigm. However, under CRT, exercise improved movement execution and information processing: total time was significantly reduced from 814 to 747 ms (p < 0.001), reaction time improved from 543 to 502 ms (p < 0.001), movement time improved from 270 to 246 ms (p = 0.01), and movement velocity improved from 28 cm/sec to 30 cm/sec (p = 0.01). Improvements in total time and reaction time in the CRT paradigm persisted 4 and 8 weeks following exercise cessation. Antiparkinsonian medication improved motor execution, but not information processing. The improvement in information processing following aerobic exercise, but not levodopa administration, suggests high intensity exercise may be enhancing neural processing and non-motor pathways outside those impacted by medication. The persistence of symptom improvement despite exercise intervention cessation indicates exercise is a candidate for disease modification. Trial registration: The trial was first registered at ClinicalTrials.gov on 7/10/2012 under registration number NCT01636297.

Indexed as

Parkinson DiseaseAntiparkinson AgentsExerciseExercise TherapyHumansLevodopaAntiparkinson AgentsLevodopaAerobic exerciseDiseaseInformation processingParkinson’sReaction time

Identifiers

PMID33394100
PMCPMC13040507
OpenAlexW3121050165

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.