Evidence map›Paper›PMID 33394083›Full record

ReviewCurrent microbiology2021

Psychobiotics: The Next-Generation Probiotics for the Brain.

Richa Sharma, Deesha Gupta, Rekha Mehrotra, Payal Mago

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Current microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06765057 (Effect of Probiotics "Psychobiotics" on Depression in Adults With Pre-Metabolic Syndrome and Metabolic Syndrome in Riyadh City), which is not on this map. Cited by 65 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 5 pooled it
7.1field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06765057 phase2 / phase3recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Probiotics "Psychobiotics" on Depression in Adults With Pre-Metabolic Syndrome and Metabolic Syndrome in Riyadh City

TypeinterventionalSponsorRoaa Ahmed AlkreadeesRan2025 to 2027Enrolled60ConditionsDepression Anxiety DisorderArmsWinclove's Ecologic® Barrier Probiotics, Winclove's Ecologic® Barrier Probiotics Placebo
3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 5 syntheses or guidelines pooled it, 142 citations in OpenAlex.

  1. Pooled it
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  6. Effects ofNutrients · 2024
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  9. Nutraceutical Applications ofFoods (Basel, Switzerland) · 2026
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5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Richa SharmaDepartment of Microbiology, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, New Delhi, 110096, India. richa2912@gmail.com.ORCID http://orcid.org/0000-0003-2773-5843
Deesha GuptaDepartment of Microbiology, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, New Delhi, 110096, India.
Rekha MehrotraDepartment of Microbiology, Shaheed Rajguru College of Applied Sciences for Women, University of Delhi, New Delhi, 110096, India.
Payal MagoShaheed Rajguru College of Applied Sciences for Women, University of Delhi, New Delhi, India.
University of Delhi · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Psychobiotics are a special class of probiotics, which deliver mental health benefits to individuals. They differ from conventional probiotics in their ability to produce or stimulate the production of neurotransmitters, short-chain fatty acids, enteroendocrine hormones and anti-inflammatory cytokines. Owing to this potential, psychobiotics have a broad spectrum of applications ranging from mood and stress alleviation to being an adjuvant in therapeutic treatment for various neurodevelopment and neurodegenerative disorders. The common psychobiotic bacteria belong to the family Lactobacilli, Streptococci, Bifidobacteria, Escherichia and Enterococci. The two-way crosstalk between the brain and the gastrointestinal system is influenced by these bacteria. The neurons present in the enteric nervous system interact directly with the neurochemicals produced by microbiota of the gut, thereby influencing the signaling to central nervous system. The present review highlights the scope and advancements made in the field, enlisting numerous commercial psychobiotic products that have flooded the market. In the latter part we discuss the potential concerns with respect to psychobiotics, such as the effects due to withdrawal, compatibility with immunocompromised patients, and the relatively unregulated probiotic market.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaProbioticsBrainFatty Acids, VolatileHumansFatty Acids, Volatile

Identifiers

PMID33394083
OpenAlexW3119223828

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.