ArticleeLife2021
Dentate gyrus development requires a cortical hem-derived astrocytic scaffold.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 18 citations in OpenAlex.
- Inverse and dynamic levels of H3K4me3 and H3K27me3 regulate mouse postnatal dental gyrus development.Cell death and differentiation · 2026Article
- In Utero Electroporation Uncovers an Early-Differentiating Subset of Dentate Gyrus Progenitors.Cellular and molecular neurobiology · 2025Article
- Beyond the canonical niche: how astrocytes carried neurogenic potential into the brain parenchyma.Frontiers in cell and developmental biology · 2025Review
- KDM2B regulates hippocampal morphogenesis by transcriptionally silencing Wnt signaling in neural progenitors.Nature communications · 2023Article
- Lmx1a is a master regulator of the cortical hem.eLife · 2023Article
- Dentate gyrus morphogenesis is regulated by β-catenin function in hem-derived fimbrial glia.Development (Cambridge, England) · 2022Article
- The cortical hem lacks stem cell potential despite expressing SOX9 and HOPX.Developmental neurobiology · 2022Article
- Glia Not Neurons: Uncovering Brain Dysmaturation in a Rat Model of Alzheimer's Disease.Biomedicines · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
During embryonic development, radial glial cells give rise to neurons, then to astrocytes following the gliogenic switch. Timely regulation of the switch, operated by several transcription factors, is fundamental for allowing coordinated interactions between neurons and glia. We deleted the gene for one such factor, SOX9, early during mouse brain development and observed a significantly compromised dentate gyrus (DG). We dissected the origin of the defect, targeting embryonic
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.