Evidence map›Paper›PMID 33393790›Full record

ArticleJournal of proteome research2021

Metaproteomics Analysis of SARS-CoV-2-Infected Patient Samples Reveals Presence of Potential Coinfecting Microorganisms.

Peter S Thuy-Boun, Subina Mehta, Bjoern Gruening, Thomas McGowan, An Nguyen, Andrew T Rajczewski, James E Johnson, Timothy J Griffin, Dennis W Wolan, Pratik D Jagtap

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

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  12. The Complexity of Co-Infections in the Era of COVID-19.SN comprehensive clinical medicine · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Peter S Thuy-BounScripps Research, La Jolla, California 92037, United States.
Subina MehtaUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-9818-0537
Bjoern GrueningBioinformatics Group, Department of Computer Science, University of Freiburg, 79110 Freiburg im Breisgau, Germany.ORCID 0000-0002-3079-6586
Thomas McGowanUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.
An NguyenUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.
Andrew T RajczewskiUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.
James E JohnsonUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.
Timothy J GriffinUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0001-6801-2559
Dennis W WolanScripps Research, La Jolla, California 92037, United States.ORCID 0000-0001-9879-8353
Pratik D JagtapUniversity of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID 0000-0003-0984-0973
University of Minnesota · USScripps Institution of Oceanography · USUniversity of Freiburg · DE

Funding

Expanding multiplexed kinase biosensor analysis to SWATH-MS (Part 2 of 2)U24CA199347 · NCI · UNIVERSITY OF MINNESOTA · PI GRIFFIN, TIMOTHY J. · 2016 to 2019
$2.4M
NCI NIH HHS U24 CA199347
6 · The paper itself

Abstract

In this Letter, we reanalyze published mass spectrometry data sets of clinical samples with a focus on determining the coinfection status of individuals infected with SARS-CoV-2 coronavirus. We demonstrate the use of ComPIL 2.0 software along with a metaproteomics workflow within the Galaxy platform to detect cohabitating potential pathogens in COVID-19 patients using mass spectrometry-based analysis. From a sample collected from gargling solutions, we detected

Indexed as

AcinetobacterBacterial InfectionsCoinfectionCOVID-19HumansMass SpectrometryNasopharynxProteomicsPseudomonasSARS-CoV-2Streptococcus pneumoniae

Identifiers

PMID33393790
PMCPMC7805602
OpenAlexW3118944290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.