ArticleeLife2021
Epithelial colonies in vitro elongate through collective effects.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Generic comparison of lumen nucleation and fusion in epithelial organoids with and without hydrostatic pressure.Nature communications · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Substrate stress relaxation regulates monolayer fluidity and leader cell formation for collectively migrating epithelia.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- StretchView - A Multi-Axial Cell-Stretching Device for Long-Term Automated Videomicroscopy of Living Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Mechanical strain focusing at topological defect sites in regenerating Hydra.Development (Cambridge, England) · 2025Article
- Local polar order controls mechanical stress and triggers layer formation in Myxococcus xanthus colonies.Nature communications · 2025Article
- Long-range organization of intestinal 2D-crypts using exogenous Wnt3a micropatterning.Nature communications · 2025Article
- Strings and topological defects govern ordering kinetics in endothelial cell layers.Nature physics · 2025Article
- Stress-shape misalignment in confluent cell layers.Nature communications · 2024Article
- Cyclic stretching combined with cell-cell adhesion is sufficient for inducing cell intercalation.Biophysical journal · 2023Article
- Article
- Collective rotational motion of freely expanding T84 epithelial cell colonies.Journal of the Royal Society, Interface · 2023Article
- Mechanical stress driven by rigidity sensing governs epithelial stability.Nature physics · 2023Article
- Pulsations and flows in tissues as two collective dynamics with simple cellular rules.iScience · 2022Article
- Active T1 transitions in cellular networks.The European physical journal. E, Soft matter · 2022Article
- Implementation of cellular bulk stresses in vertex models of biological tissues.The European physical journal. E, Soft matter · 2022Article
- Article
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Authors and funding
9 authors.
Funding
Abstract
Epithelial tissues of the developing embryos elongate by different mechanisms, such as neighbor exchange, cell elongation, and oriented cell division. Since autonomous tissue self-organization is influenced by external cues such as morphogen gradients or neighboring tissues, it is difficult to distinguish intrinsic from directed tissue behavior. The mesoscopic processes leading to the different mechanisms remain elusive. Here, we study the spontaneous elongation behavior of spreading circular epithelial colonies in vitro. By quantifying deformation kinematics at multiple scales, we report that global elongation happens primarily due to cell elongations, and its direction correlates with the anisotropy of the average cell elongation. By imposing an external time-periodic stretch, the axis of this global symmetry breaking can be modified and elongation occurs primarily due to orientated neighbor exchange. These different behaviors are confirmed using a vertex model for collective cell behavior, providing a framework for understanding autonomous tissue elongation and its origins.
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Registered trials
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