Evidence map›Paper›PMID 33393458›Full record

ArticleeLife2021

Interplay of opposing fate choices stalls oncogenic growth in murine skin epithelium.

Madeline Sandoval, Zhe Ying, Slobodan Beronja

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Madeline SandovalDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States.
Zhe YingDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States.
Slobodan BeronjaDivision of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, United States.ORCID 0000-0002-6769-9261
Fred Hutch Cancer Center · USUniversity of Washington · US

Funding

Translational Bioimaging Core Shared ResourceP30CA015704 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Eric Collisson · 1985 to 2026
$296.4M
TRAINING IN MOLECULAR AND CELLULAR BIOLOGYT32GM007270 · NIGMS · UNIVERSITY OF WASHINGTON · PI RAIBLE, DAVID W · 1985 to 2020
$21.0M
Differentiation balances oncogene-driven proliferation to maintain epidermal homeostasisR01AR070780 · NIAMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI Slobodan Beronja · 2017 to 2026
$4.2M
Functional exploration of progenitor renewal and differentiation in oral epithelial homeostasis and cancerR00DE029229 · NIDCR · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI YING, ZHE · 2021 to 2023
$744k
Functional exploration of progenitor renewal and differentiation in oral epithelial homeostasis and cancerK99DE029229 · NIDCR · FRED HUTCHINSON CANCER RESEARCH CENTER · PI YING, ZHE · 2019 to 2020
$325k
NCI NIH HHS P30 CA015704NIAMS NIH HHS R01 AR070780NIDCR NIH HHS K99 DE029229NIDCR NIH HHS R00 DE029229NIGMS NIH HHS T32 GM007270
6 · The paper itself

Abstract

Skin epithelium can accumulate a high burden of oncogenic mutations without morphological or functional consequences. To investigate the mechanism of oncogenic tolerance, we induced Hras

Indexed as

Adaptor Proteins, Signal TransducingAnimalsApoptosis Regulatory ProteinsCarcinogenesisEpidermal CellsEpithelial CellsEpitheliumFemaleGenes, rasMaleMiceMice, Inbred C57BLSingle-Cell AnalysisSkinAdaptor Proteins, Signal TransducingApoptosis Regulatory ProteinsRassf5 protein, mousecancer biologycell fate choicemouseoncogene toleranceregenerative medicineskin epitheliumstem cells

Identifiers

PMID33393458
PMCPMC7817173
OpenAlexW3036568862

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.