ReviewCurrent osteoporosis reports2021
The Use of Platelet-Rich Plasma (PRP) for the Management of Non-union Fractures.
Review in Current osteoporosis reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- Efficacy and safety of biological agents and physical therapies for delayed union or nonunion of fractures: a network meta-analysis of randomized controlled trials.BMC musculoskeletal disorders · 2026Pooled it
- Arthroscopic surgery for scaphoid nonunion: a 10-year systematic literature review.Musculoskeletal surgery · 2024Pooled it
- Therapeutic Potential of Platelet-Rich Plasma in Canine Medicine.Archives of Razi Institute · 2021Pooled it
- Use of Autologous Platelet-rich Plasma as a Biological Adjunct in Distal Humerus Non-union: A Case Report.Journal of orthopaedic case reports · 2026Article
- PRP-related biomaterials enhance bone and nerve repair.Materials today. Bio · 2026Review
- Induced membrane-mediated DBM in combination with PRP: an autologous bone graft substitute therapy with remarkable osteoformation potency for challenging bone defects.International journal of surgery (London, England) · 2026Article
- Immunomodulation by platelet-derived DKK1: potential for controlling disease and pathology in leishmaniasis and implications for other infectious diseases.Frontiers in immunology · 2026Review
- Platelet-rich plasma for the treatment of postoperative anastomotic fistula of the gastrointestinal tract: a case report.Frontiers in pharmacology · 2026Article
- Platelet-rich plasma-contained drug delivery systems to treat orthopedic injuries.International journal of pharmaceutics: X · 2025Review
- Platelet-rich plasma enhanced therapy for aseptic atrophic tibial diaphyseal nonunion: a single-center retrospective controlled study of 90 cases.Journal of orthopaedic surgery and research · 2025Article
- Cytokine Profiling of Exudates from Periapical Lesions and the Efficacy of CXCL10 as a Healing Marker.Pathogens (Basel, Switzerland) · 2025Article
- Role of Ortho Biologics in Subtrochanteric Osteotomy Non-union in a Case of Developmental Hip Dysplasia Managed with Total Hip Replacement - A Case Report.Journal of orthopaedic case reports · 2025Article
- Bioregenerative autologous scaffold made from bone marrow aspirate concentrate, cancellous bone autograft, platelet-rich plasma, and autologous fibrin to treat non-unions of the femur, humerus, and forearm bones: a case series.Regenerative medicine · 2025Article
- Regional Gene Therapy for Bone Tissue Engineering: A Current Concepts Review.Bioengineering (Basel, Switzerland) · 2025Review
- Platelet-rich plasma-enhanced "plum blossom" bone grafting for refractory femoral nonunion: a single-center study of 33 cases.Frontiers in bioengineering and biotechnology · 2025Article
- A study on early diagnosis for fracture non-union prediction using deep learning and bone morphometric parameters.Frontiers in medicine · 2025Article
- Evaluation of the Role of PRP in Acute Tibial Shaft Fractures Fixation With IM Nail: A Double-Blinded Randomized Controlled Trial.Advances in orthopedics · 2025Article
- Case Report: Based on the diamond theory, successful treatment of stubborn tibial nonunion after six surgeries using PRP-augmented therapy: a case report and literature review.Frontiers in surgery · 2025Article
- Dual locking plate fixation, PRP-augmented autologous bone grafting, and bioactive core construction for femoral fracture nonunion: a retrospective study of 52 cases.Frontiers in medicine · 2025Article
- Autologous Growth Factor-Rich Concentrate (GFC) Injection in Non-union of Fractures: A Quasi-experimental Study.Indian journal of orthopaedics · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewThe treatment of non-union fractures represents a significant challenge for orthopaedic surgeons. In recent years, biologic agents have been investigated and utilised to support and improve bone healing. Among these agents, platelet-rich plasma (PRP) is an emerging strategy that is gaining popularity. The aim of this review is to evaluate the current literature regarding the application and clinical effectiveness of PRP injections, specifically for the treatment of non-union fractures. RECENT
findingsThe majority of published studies reported that PRP accelerated fracture healing; however, this evidence was predominantly level IV. The lack of randomised, clinical trials (level I-II evidence) is currently hampering the successful clinical translation of PRP as a therapy for non-union fractures. This is despite the positive reports regarding its potential to heal non-union fractures, when used in isolation or in combination with other forms of treatment. Future recommendations to facilitate clinical translation and acceptance of PRP as a therapy include the need to investigate the effects of administering higher volumes of PRP (i.e. 5-20 mL) along with the requirement for more prolonged (> 11 months) randomised clinical trials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.