Evidence map›Paper›PMID 33393007›Full record

ArticleMolecular biology reports2021

Mangiferin, a naturally occurring polyphenol, mitigates oxidative stress induced premature senescence in human dermal fibroblast cells.

Rashi Kanoi, Pooja Loachan, Shubhankar Das, Bola Sadashiva Satish Rao

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular biology reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
3.0field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Ectoine attenuates HFrontiers in aging · 2026
    Article
  2. Review
  3. Endothelial-Protective Actions of Diethylether Extract fromInternational journal of molecular sciences · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Preventive Effect of Nuciferine on HMolecules (Basel, Switzerland) · 2022
    Article
  10. Review
  11. Skin Aging, Cellular Senescence and Natural Polyphenols.International journal of molecular sciences · 2021
    Review
  12. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 1 country.

Rashi KanoiDepartment of Biotechnology, Manipal School of Life Sciences, Manipal Academy of Higher Education, 576104, Manipal, Karnataka, India.
Pooja LoachanInstitute of Human Genetics, Jammu University, Jammu, Jammu & Kashmir, 180006, India.
Shubhankar DasDepartment of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.ORCID https://orcid.org/0000-0002-8044-532X
Bola Sadashiva Satish RaoDepartment of Radiation Biology and Toxicology, Manipal School of Life Sciences, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India. rao.satish@manipal.edu.ORCID http://orcid.org/0000-0002-9631-9731
Manipal Academy of Higher Education · INUniversity of Jammu · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic oxidative stress has been associated with several human ailments including the condition of aging. Extensive studies have shown the causal relationship between oxidative stress, aging, and cellular senescence. In this regard, forestalling or preventing senescence could delay the aging process as well as act as an intervention against premature aging. Hence, in the present study, we investigated the anti-senescence potential of Mangiferin (MGN) against Hydrogen peroxide (H

Indexed as

AgingAntioxidantsApoptosisCell CycleCells, CulturedCell SurvivalCellular SenescenceFibroblastsHumansMembrane Potential, MitochondrialOxidative StressPolyphenolsReactive Oxygen SpeciesXanthonesAntioxidantsmangiferinPolyphenolsReactive Oxygen SpeciesXanthonesG0/G1 arrestOxidative stressPolyphenolsSenescence

Identifiers

PMID33393007
OpenAlexW3118283761

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.