Evidence map›Paper›PMID 33392937›Full record

ArticleInflammation2021

Betulin Alleviates Myocardial Ischemia-Reperfusion Injury in Rats via Regulating the Siti1/NLRP3/NF-κB Signaling Pathway.

Chenchen Yu, Xixi Cai, Xuejiao Liu, Jianlong Liu, Na Zhu

Abstract read
PubMed Publisher
In one paragraph

Article in Inflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chenchen YuDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
Xixi CaiDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
Xuejiao LiuDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
Jianlong LiuDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China. liujianlongmz@163.com.ORCID http://orcid.org/0000-0002-2384-8456
Na ZhuDepartment of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325015, China.
Wenzhou Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To study the effects of betulin (BE) on myocardial ischemia-reperfusion (I/R) injury in rats, electrocardiogram (ECG) was detected by an electrocardiograph; myocardial infarction was evaluated by triphenyltetrazolium (TTC) staining, serum biochemical indicators myocardial enzymes creatine kinase (CK), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), serum superoxide dismutase (SOD), glutathione (GSH), nitric oxide (NO), and malondialdehyde (MDA); and inflammatory cytokines were tested by using commercial kits. The expression of the Siti1/NLRP3/NF-κB signaling pathway was detected by western blotting and immunohistochemistry experiments. BE improved ECG; reduced myocardial infarction area; decreased CK, LDH, AST, MDA, NO, and inflammatory cytokines; and increased SOD and GSH in I/R rats. In addition, BE also increased Siti1 and decreased the NLRP3/NF-κB signaling pathway in I/R rats. This study shows that the protection of BE is associated with changes in the Siti1/NLRP3/NF-κB pathway.

Indexed as

AnimalsAnti-Inflammatory AgentsBetulinic AcidCytokinesDisease Models, AnimalHeart RateMyocardial Reperfusion InjuryMyocytes, CardiacNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinOxidative StressRatsRats, WistarSignal TransductionSirtuin 1TriterpenesAnti-Inflammatory AgentsbetulinBetulinic AcidCytokinesNF-kappa BNLR Family, Pyrin Domain-Containing 3 ProteinNlrp3 protein, ratSirt1 protein, ratSirtuin 1Triterpenesbetulinmyocardial ischemia–reperfusionSiti1/NLRP3/NF-κB pathway

Identifiers

PMID33392937
OpenAlexW3119194142

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.