Evidence map›Paper›PMID 33392932›Full record

ArticleMaternal and child health journal2021

Indeterminate Prenatal Ultrasounds and Maternal Anxiety: A Prospective Cohort Study.

Marielle S Gross, Hyeyoung Ju, Lauren M Osborne, Eric B Jelin, Priya Sekar, Angie C Jelin

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Article in Maternal and child health journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

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5citing papers in PubMed
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1 · What the graph read from it

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3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Marielle S GrossJohns Hopkins Berman Institute of Bioethics, 1809 Ashland Ave, Baltimore, MD, 21205, USA. mgross23@jhmi.edu.ORCID http://orcid.org/0000-0002-3009-4082
Hyeyoung JuDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Women's Mood Disorders Center, 550 N. Broadway, Suite 305, Baltimore, MD, 21205, USA.
Lauren M OsborneDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Women's Mood Disorders Center, 550 N. Broadway, Suite 305, Baltimore, MD, 21205, USA.
Eric B JelinChildren's Center Fetal Program, Johns Hopkins Children's Center, 1800 Orleans Street, Baltimore, MD, M230721287, USA.
Priya SekarPediatric Cardiology, Johns Hopkins Children's Center, 1800 Orleans Street, Baltimore, MD, M230721287, USA.
Angie C JelinDepartment of Gynecology and Obstetrics, Johns Hopkins University School of Medicine, Women's Mood Disorders Center, 550 N. Broadway, Suite 305, Baltimore, MD, 21205, USA.

Funding

Biological Mechanisms of Perinatal AnxietyK23MH110607 · NIMH · JOHNS HOPKINS UNIVERSITY · PI OSBORNE, LAUREN M · 2017 to 2021
$985k
NIMH NIH HHS K23 MH110607
6 · The paper itself

Abstract

introductionPrenatal ultrasounds often yield indeterminate (incomplete or minor abnormality) findings with limited clinical utility. We evaluate impact of indeterminate findings on maternal anxiety.

methodsA single-U.S.-center prospective cohort study administered the Perinatal Anxiety Screening Scale (PASS; control mean = 13.4; > 20 denotes clinically significant anxiety) before and after prenatal ultrasounds in February-May 2017. Ultrasound reports were coded as: normal; indeterminate; or major abnormality. Primary outcome was anxiety after indeterminate vs. normal ultrasounds. Secondary outcomes included anxiety change from pre-to-post-ultrasound and relative to women's characteristics. Linear regression adjusted for confounders.

resultsOf 286 ultrasounds, 51.0% were normal, 40.5% indeterminate (22.0% incomplete; 18.5% minor abnormality), and 8.0% major abnormalities. Indeterminate findings were unrelated to age, race, parity, infertility, or psychiatric history, but associated with gestational age (26.6%/45.0%/52.5% for first/second/third trimesters; p < 0.001), and obesity (48.8 vs. 37.0%; p = 0.031). Pretest anxiety was highest in second/third trimesters (p = 0.029), and in subjects aged age ≤ 24 or younger(p < 0.001), with a history of anxiety (p < 0.001),) or with prior pregnancy loss (p = 0.011). Mean anxiety score decreased pre-to-posttest across all groups. Indeterminate findings were associated with higher PASS scores than normal findings: pretest 20.1 vs. 16.4 (p = 0.026) and posttest 16.9 vs. 12.2 (p = 0.009; adjusted-p = 0.01). Versus normal ultrasounds, incomplete findings were associated with higher post-ultrasound anxiety (p = 0.007; adjusted-p = 0.01) and smaller decreases from pre-to-posttest (adjusted-p = 0.03), whereas minor abnormalities had higher pretest anxiety (p = 0.029) with larger pre-to-posttest decreases (adjusted-p =0.010). DISCUSSION: Indeterminate ultrasounds, especially incomplete findings, are associated with significantly higher anxiety than normal findings, suggesting need for evidence-based counseling, management and strategies for decreasing number of indeterminate results.

Indexed as

Anxiety DisordersUltrasonography, PrenatalAgedAnxietyFemaleHumansPregnancyPregnancy Trimester, ThirdProspective StudiesIncomplete findingsMaternal anxietyMinor abnormalityPrenatal ultrasoundSoft marker

Identifiers

PMID33392932
PMCPMC8062287

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.