ArticleInternational journal of bipolar disorders2021
Has Bipolar Disorder become a predominantly female gender related condition? Analysis of recently published large sample studies.
Article in International journal of bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 76 citations in OpenAlex.
- Bipolar Early Intervention Using New Digital Technologies (BLEND): A Pilot Randomised Controlled Trial of a Novel Blended-Digital Early Intervention Model of Care for Youth With Bipolar Disorder I or II.Early intervention in psychiatry · 2025Trial
- Comparative Analysis of the Burden of Bipolar Disorder Among Individuals Aged 15-49 Years in China and Globally, 1990-2021: An Ecological Trend Analysis Based on GBD 2021.Health science reports · 2026Article
- Diagnostic and sex effects on frontostriatal brain wiring structural organization in early psychosis affective subjects compared to healthy controls.Molecular psychiatry · 2026Article
- The Estrogen-Mitochondria Axis in Bipolar Disorder: From Fluctuating Hormones to Failing Bioenergetics.Biological psychiatry global open science · 2026Review
- Sex differences in prevalence and clinical correlates for psychotic symptoms in first-episode drug-naïve patients with bipolar disorder: a cross-sectional study.Annals of general psychiatry · 2026Article
- Gender differences in symptom profiles of individuals being treated for mood disorders.Journal of mood and anxiety disorders · 2025Article
- Bipolar II disorder: a state-of-the-art review.World psychiatry : official journal of the World Psychiatric Association (WPA) · 2025Article
- Gender Differences in Depressive Disorders in Children and Adolescents: Results from a Clinical Sample.Maedica · 2025Article
- Generalizability of findings from four clinical cohort studies and a general population study to patients with bipolar I disorder in outpatient treatment in the Netherlands.International journal of bipolar disorders · 2025Article
- Trends, geographic distribution, and disease burden of bipolar disorder in Ecuador (2011-2021): An analysis of hospital discharge data.PloS one · 2025Observational
- Bipolar disorders: an update on critical aspects.The Lancet regional health. Europe · 2025Review
- Influence of immunological awareness on enhancing the overall complying with health instructions and necessary vaccines during epidemics and pandemics.Human vaccines & immunotherapeutics · 2024Article
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- Investigating sex-related differences in brain structure and function in bipolar I disorder using multimodal MRI.BMC psychiatry · 2024Article
- Article
- Understanding Internalized Stigma's Role in Sex-Specific Suicidal Ideation among Individuals with Bipolar Disorder.Journal of clinical medicine · 2024Article
- Managing a Complex Case of Bipolar Disorder in a Patient With Recurrent Hospitalizations.Cureus · 2024Article
- Lithium-Associated Kidney Failure: Predictors and Outcomes.Kidney international reports · 2024Article
- P2X7 receptor inhibition alleviates mania-like behavior independently of interleukin-1β.iScience · 2024Article
- Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar Disorders (BD) are disabling and severe psychiatric disorders, commonly perceived as equally affecting both men and women. The prevalence of BD in the general population has been growing over the last decade, however, few epidemiological studies are available regarding BD gender distribution, leaving unanswered the question whether the often reported increment of BD diagnosis could be gender specific. In fact, BD in female patients can often be misdiagnosed as MDD, leaving such women non correctly treated for longer times than their male counterparts. From this perspective, we searched literature for large sample (> 1000 subjects) studies published in the last decade (2010 onward) on BD patients. We included ten large sample studies that reported the gender distribution of their samples, and we therefore analysed them. Our results show a higher preponderance of female patients in every sample and sub-sample of BDI and BDII, supporting our hypothesis of an increase in BD diagnosis in females. BD in women presents with higher rates of rapid cycling, depressive polarity and suicide attempts, characteristics of non inferior severity compared to males; prompt recognition and adequate treatment of BD is therefore crucial to reduce risks and improve quality of life of affected women. In this regard, our results could lead the way for national or international epidemiological studies with the aim of more accurately assessing gender-specific prevalence of BD.
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Registered trials
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