Evidence map›Paper›PMID 33392842›Full record

Trial reportBreast cancer research and treatment2021

The INTEND 1 randomized controlled trial of duct endoscopy as an indicator of margin excision in breast conservation surgery.

Gerald Gui, Effrosyni Panopoulou, Sarah Tang, Dominique Twelves, Mohammed Kabir, Ann Ward, Catherine Montgomery, Ashutosh Nerurkar, Peter Osin, Clare M Isacke

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Breast cancer research and treatment, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 65% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 synthesis or guideline pooled it, 1 citations in OpenAlex.

  1. Pooled it
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Gerald GuiDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK. gerald.gui@rmh.nhs.uk.
Effrosyni PanopoulouDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK.ORCID http://orcid.org/0000-0002-4931-4874
Sarah TangDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK.
Dominique TwelvesDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK.
Mohammed KabirDepartment of Clinical Research and Development, Royal Marsden NHS Trust, London, UK.
Ann WardDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK.
Catherine MontgomeryDepartment of Surgery, Royal Marsden NHS Trust, London, SW3 6JJ, UK.
Ashutosh NerurkarDepartment of Histopathology, Royal Marsden NHS Trust, London, UK.
Peter OsinDepartment of Histopathology, Royal Marsden NHS Trust, London, UK.
Clare M IsackeThe Breast Cancer Now Toby Robins Research Centre, Institute of Cancer Research, London, UK.
Royal Marsden NHS Foundation Trust · GBInstitute of Cancer Research · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWith early detection, breast conservation surgery with adequate surgical margins is the standard of care. The aim of this study was to evaluate the use of pre-operative duct endoscopy (DE) to target surgical resection, improve adequate margins and reduce re-excision operations.

methodsWomen with DCIS, stage I and II breast cancer suitable for breast conservation were randomized to DE-assisted wide local excision versus standard wide local excision (without DE). The primary endpoint was margin re-excision rates between the two groups. Secondary end points were: (i) volume differences of the surgical specimen; (ii) whether an extensive in situ component (EIC) influenced successful DE-guided resection.

results78 women were randomized: 44 patients to no-DE and 34 patients to the DE group. The median age was 59 (49-65) and 56 (48-64) years in the two groups respectively with mean follow-up of 9.1 (4.2-11.1) years. There were 23 positive findings in 17 women in 30 successful DE procedures (17/30 = 56.7%). The surgical specimen volume, no-DE (17 [IQR 10-29] cm

conclusionsThis randomized clinical trial was limited by incomplete accrual. DE did not contribute to improved margin excision rates whether a target lesion was visualized or not. The presence of EIC did not improve efficacy of DE.

Indexed as

Breast NeoplasmsCarcinoma, Ductal, BreastBreastEndoscopyFemaleHumansMastectomy, SegmentalMiddle AgedBreast conservation surgeryDuct endoscopyRe-excisionSurgical margins

Identifiers

PMID33392842
OpenAlexW3121121491

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.