ArticleInternational journal of bipolar disorders2021
Chronic kidney disease in lithium-treated patients, incidence and rate of decline.
Article in International journal of bipolar disorders, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Psychotropic Drugs and Adverse Kidney Effects: A Systematic Review of the Past Decade of Research.CNS drugs · 2022Pooled it
- Lithium in Bipolar Disorder: Renal Mechanisms, Nephrotoxicity Phenotypes, and a Shared-Care Pathway for Clinical Practice.International journal of molecular sciences · 2026Review
- Perspective: Taxonomy of Kidney Diseases and Disorders Related to Nephrotoxic Drug Exposure in Hospitalized Patients.Mayo Clinic proceedings · 2026Article
- Lithium effects on renal functioning: an expert opinion and management algorithm.International journal of bipolar disorders · 2026Article
- Analysing lithium, quetiapine and valproic acid on social media: an infodemiology study.International journal of bipolar disorders · 2025Article
- Managing bipolar affective disorder in chronic kidney disease when lithium is no longer an option.BMJ case reports · 2025Article
- Article
- Lithium for Bipolar Disorder and Risk of Thyroid Dysfunction and Chronic Kidney Disease.JAMA network open · 2025Article
- Lithium: current state of the art and future directions.International journal of bipolar disorders · 2024Review
- Chronic kidney disease incidences in Thai outpatients diagnosed with psychiatric illnesses receiving lithium maintenance therapy: a university hospital-based study.BMC psychiatry · 2024Article
- Molecular mechanisms and therapeutic potential of lithium in Alzheimer's disease: repurposing an old class of drugs.Frontiers in pharmacology · 2024Review
- Lifetime risk of severe kidney disease in lithium-treated patients: a retrospective study.International journal of bipolar disorders · 2023Article
- Key questions on the long term renal effects of lithium: a review of pertinent data.International journal of bipolar disorders · 2023Review
- Lithium Therapy in COVID-19 with Bipolar Affective Disorder-A Case Series.Indian journal of psychological medicine · 2023Article
- Chronic kidney disease and severe mental illness: a scoping review.Journal of nephrology · 2023Article
- The low risk for early renal damage during lithium treatment has not changed over time.Journal of psychopharmacology (Oxford, England) · 2023Article
- Lithium and the risk of chronic kidney disease: A population-based case-control study.Basic & clinical pharmacology & toxicology · 2022Article
- Safety and Efficacy of Combined Low-Dose Lithium and Low-Dose Aspirin: A Pharmacological and Behavioral Proof-of-Concept Study in Rats.Pharmaceutics · 2021Article
- The Clinical and Economic Burden of Tardive Dyskinesia in Israel: Real-World Data Analysis.Journal of clinical psychopharmacologyArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLithium-induced nephropathy is a known long-term complication, sometimes limiting the use of lithium as mood stabilizer. The aim of this study is to establish the incidence of chronic kidney disease and the rate of decline of renal function in patients using lithium and to identify risk factors.
methodsWe selected 1012 patients treated with lithium from the laboratory database of the Antes Centre for Mental Health Care spanning a period from 2000 to 2015. Serum lithium and creatinine concentrations were retrieved and eGFR was calculated using the 4-variable CKD-EPI formula. We calculated the incidence of renal insufficiency and the rate of decline. We compared patients with and without chronic kidney disease (CKD) stage 3 regarding duration of lithium exposure.
resultsIncidence of chronic kidney disease was 0.012 cases per exposed patient-year. Average decline of eGFR was 1.8 ml/min/year in patients who developed chronic kidney disease stage 3. Incidence of chronic kidney disease stage 4 was only 0.0004 per patient year. No cases of end stage renal disease were found in this cohort. Odds of reaching chronic kidney disease stage 3 were increased with longer duration of lithium exposure.
conclusionsThe use of lithium seems to be related to a higher incidence of chronic kidney disease. Longer duration of lithium exposure significantly increased the risk of renal failure.
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