Evidence map›Paper›PMID 33392798›Full record

ArticleVirchows Archiv : an international journal of pathology2021

A report of a patient presenting with three metachronous 13q14LOH mesenchymal tumours: spindle cell lipoma, cellular angiofibroma and mammary myofibroblastoma.

Andrea Cordaro, Harry R Haynes, Timothy Murigu, Michael Michal, Francesca Maggiani, Demetris Poyiatzis, Abigail Palmer, Zsombor Melegh

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Andrea CordaroWelsh Institute of Dermatology, University Hospital of Wales, Cardiff, UK. ac12370@my.bristol.ac.uk.ORCID https://orcid.org/0000-0002-7531-2039
Harry R HaynesGreat Western Hospital and Department of Translational Health Sciences, University of Bristol, Bristol, UK.ORCID https://orcid.org/0000-0001-6468-7671
Timothy MuriguDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.
Michael MichalDepartment of Pathology, Faculty of Medicine in Plzen, Charles University, Prague, Czech Republic.
Francesca MaggianiDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.
Demetris PoyiatzisDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.
Abigail PalmerBristol Genetics Department, North Bristol NHS Trust, Bristol, UK.
Zsombor MeleghDepartment of Cellular Pathology, North Bristol NHS Trust, Bristol, UK.ORCID https://orcid.org/0000-0001-7605-5719
North Bristol NHS Trust · GBCharles University · CZGreat Western Hospital · GBUniversity Hospital of Wales · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spindle cell lipoma, cellular angiofibroma and mammary myofibroblastoma are mesenchymal tumours that have overlapping morphological and immunophenotypic features. Aberrations in chromosome 13q14 have been identified as a recurrent feature. We report a unique case of a 69-year-old woman who metachronously developed all three tumours. She developed a peri-urethral and a recurrent peri-vaginal cellular angiofibroma at age 54 and 57, respectively, a spindle cell lipoma at age 62 and a mammary myofibroblastoma at age 69. Dual-colour interphase fluorescent in situ hybridisation (FISH) revealed losses of RB1 and FOXO1 (13q14LOH [loss of heterozygosity]) within neoplastic cells. There was also loss of retinoblastoma (Rb) protein expression. To our knowledge, this is the first report of these three tumours arising in the same patient. The genetic link between these tumours supports the hypothesis that they may arise from the same progenitor cells. However, further research is required to elucidate the precise pathogenetic link.

Indexed as

Chromosomes, Human, Pair 14Loss of HeterozygosityAgedAngiofibromaBiomarkers, TumorBreast NeoplasmsFemaleForkhead Box Protein O1Genetic Predisposition to DiseaseHumansIn Situ Hybridization, FluorescenceLipomaNeoplasms, Muscle TissueNeoplasms, Second PrimaryPhenotypeRetinoblastoma Binding ProteinsBiomarkers, TumorForkhead Box Protein O1FOXO1 protein, humanRB1 protein, humanRetinoblastoma Binding ProteinsUbiquitin-Protein LigasesCellular angiofibromaFISHFluorescence in situ hybridisationMammary myofibroblastomaRB1Spindle cell lipoma

Identifiers

PMID33392798
OpenAlexW3120341296

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.