ArticleIntensive care medicine2021
Ultrasound assessment of pulmonary fibroproliferative changes in severe COVID-19: a quantitative correlation study with histopathological findings.
Article in Intensive care medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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22 citing papers in PubMed, 46 citations in OpenAlex.
- Serum cytokine dysregulation signatures associated with COVID-19 outcomes in high mortality intensive care unit cohorts across pandemic waves and variants.Scientific reports · 2024Article
- Postmortem chest computed tomography in COVID-19: A minimally invasive autopsy method.European journal of radiology open · 2024Article
- COVID-19 among infants: key clinical features and remaining controversies.Clinical and experimental pediatrics · 2024Article
- Monitoring of pulmonary involvement in critically ill COVID-19 patients - should lung ultrasound be preferred over CT?The ultrasound journal · 2023Article
- Feasibility of a New Lung Ultrasound Protocol to Determine the Extent of Lung Injury in COVID-19 Pneumonia.Chest · 2023Article
- Article
- Ten Influential Point-of-Care Ultrasound Papers: 2021 in Review.Journal of intensive care medicine · 2022Article
- Current Advances in Lung Ultrasound in COVID-19 Critically Ill Patients: A Narrative Review.Journal of clinical medicine · 2022Review
- [Correlation between ultrasonography and thorax portable radiography in patients with COVID-19].Revista medica del Instituto Mexicano del Seguro Social · 2022Article
- Phenotypic heterogeneity of COVID-19 pneumonia: clinical and pathophysiological relevance of the vascular phenotype.ESC heart failure · 2022Review
- ECHOPAEDIA: Echography in Paediatric Patients in the Age of Coronavirus Disease 2019: Utility of Lung Ultrasound and Chest X-Ray in Diagnosis of Community-Acquired Pneumonia and Severe Acute Respiratory Syndrome Coronavirus 2 Pneumonia.Frontiers in pediatrics · 2022Article
- Article
- Autopsy findings of pediatric COVID-19: a systematic review.Egyptian journal of forensic sciences · 2022Article
- Ultrasound-Guided Minimally Invasive Tissue Sampling: A Minimally Invasive Autopsy Strategy During the COVID-19 Pandemic in Brazil, 2020.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Minimally Invasive Tissue Sampling as an Alternative to Complete Diagnostic Autopsies in the Context of Epidemic Outbreaks and Pandemics: The Example of Coronavirus Disease 2019 (COVID-19).Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- Italian Society of Anesthesia, Analgesia, Resuscitation, and Intensive Care expert consensus statement on the use of lung ultrasound in critically ill patients with coronavirus disease 2019 (ITACO).Journal of anesthesia, analgesia and critical care · 2021Article
- Low Dose Chest CT and Lung Ultrasound for the Diagnosis and Management of COVID-19.Journal of clinical medicine · 2021Review
- Can lung ultrasound predict histologic pattern of lung injury in critically ill patients with COVID-19? Author's reply.Intensive care medicine · 2021Article
- Lung ultrasound for the early diagnosis of COVID-19 pneumonia: an international multicenter study.Intensive care medicine · 2021Observational
- Viral mapping in COVID-19 deceased in the Augsburg autopsy series of the first wave: A multiorgan and multimethodological approach.PloS one · 2021Article
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
purposeThis study was designed to evaluate the usefulness of lung ultrasound (LUS) imaging to characterize the progression and severity of lung damage in cases of COVID-19.
methodsWe employed a set of combined ultrasound parameters and histopathological images obtained simultaneously in 28 patients (15 women, 0.6-83 years) with fatal COVID-19 submitted to minimally invasive autopsies, with different times of disease evolution from initial symptoms to death (3-37 days, median 18 days). For each patient, we analysed eight post-mortem LUS parameters and the proportion of three histological patterns (normal lung, exudative diffuse alveolar damage [DAD] and fibroproliferative DAD) in eight different lung regions. The relationship between histopathological and post-mortem ultrasonographic findings was assessed using various statistical approaches.
resultsStatistically significant positive correlations were observed between fibroproliferative DAD and peripheral consolidation (coefficient 0.43, p = 0.02) and pulmonary consolidation (coefficient 0.51, p = 0.005). A model combining age, time of evolution, sex and ultrasound score predicted reasonably well (r = 0.66) the proportion of pulmonary parenchyma with fibroproliferative DAD.
conclusionThe present study adds information to previous studies related to the use of LUS as a tool to assess the severity of acute pulmonary damage. We provide a histological background that supports the concept that LUS can be used to characterize the progression and severity of lung damage in severe COVID-19.
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