Evidence map›Paper›PMID 33392036›Full record

ArticleQuantitative imaging in medicine and surgery2021

Optical coherence tomography for the early detection of colorectal dysplasia and cancer: validation in a murine model.

Jian Ding, Qiu Li, Jiewen Lin, Shanshan He, Weiqiang Chen, Qiyong He, Qiukun Zhang, Jintong Chen, Ting Wu, Shuncong Zhong and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Quantitative imaging in medicine and surgery, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Jian DingDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Qiu LiDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Jiewen LinLaboratory of Optics, Terahertz and Non-Destructive Testing, School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, China.
Shanshan HeDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Weiqiang ChenLaboratory of Optics, Terahertz and Non-Destructive Testing, School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, China.
Qiyong HeDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Qiukun ZhangLaboratory of Optics, Terahertz and Non-Destructive Testing, School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, China.
Jintong ChenDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Ting WuDigestive Department, the First Affiliated Hospital of Fujian Medical University, Fuzhou, China.
Shuncong ZhongLaboratory of Optics, Terahertz and Non-Destructive Testing, School of Mechanical Engineering and Automation, Fuzhou University, Fuzhou, China.
Dan LiDepartment of Gastroenterology, Union Hospital, Fujian Medical University, Fuzhou, China.
First Affiliated Hospital of Fujian Medical University · CNFuzhou University · CNFujian Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is an urgent need to develop a non-invasive imaging technique for detecting colorectal dysplasia and cancer. Technology for early and real-time microscopic assessments to select the most representative biopsy sites would also be of clinical value. In this study, we explored the sensitivity of optical coherence tomography (OCT) in detecting local lesions to demonstrate its potential for the early detection of colorectal dysplasia and cancer.

methodsAn azoxymethane/dextran sodium sulfate mouse model of colorectal carcinogenesis was utilized. Mice were imaged by OCT, and colorectal tissue sections were observed with hematoxylin and eosin staining. The results of the parallel analyses were compared to evaluate the performance of OCT in imaging and early screening of colorectal lesions.

resultsDysplasia and cancer could be distinguished from normal colon tissues based on the OCT images. However, simple morphological changes observed in the OCT images were not sufficient to distinguish different degrees of dysplasia or distinguish dysplasia from cancerous tissues. The Youden index and diagnostic efficiency of OCT for colorectal dysplasia and cancer were 62.50% and 82.14%, respectively, while the sensitivity and specificity were 87.50% and 75.00%, respectively. Further, the positive and negative predictive values were 82.35% and 81.82%, respectively.

conclusionsBased on our findings, we predict that OCT is a promising non-invasive imaging technique that can offer excellent positive detection rates and diagnostic accuracy for early colorectal dysplasia and cancer. This technique is expected to be valuable in realizing real-time qualitative analysis and guided targeted biopsy.

Indexed as

colorectal carcinomadysplasiaHematoxylin-eosin staining (HE staining)tomography, optical coherence

Identifiers

PMID33392036
PMCPMC7719940
OpenAlexW3095503458

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.