ArticleWorld journal of psychiatry2020
Identification of key genes involved in post-traumatic stress disorder: Evidence from bioinformatics analysis.
Article in World journal of psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- The relationship between social adversity, micro-RNA expression and post-traumatic stress in a prospective, community-based cohort.Nature. Mental health · 2026Article
- Using Monozygotic Twins to Dissect Common Genes in Posttraumatic Stress Disorder and Migraine.Frontiers in neuroscience · 2021Article
Corrections and comments
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Authors and funding
7 authors.
Funding
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Abstract
backgroundPost-traumatic stress disorder (PTSD) is a serious stress-related disorder.
aimTo identify the key genes and pathways to uncover the potential mechanisms of PTSD using bioinformatics methods.
methodsGene expression profiles were obtained from the Gene Expression Omnibus database. The differentially expressed genes (DEGs) were identified by using GEO2R. Gene functional annotation and pathway enrichment were then conducted. The gene-pathway network was constructed with Cytoscape software. Quantitative real-time polymerase chain reaction (qRT-PCR) analysis was applied for validation, and text mining by Coremine Medical was used to confirm the connections among genes and pathways.
resultsWe identified 973 DEGs including 358 upregulated genes and 615 downregulated genes in PTSD. A group of centrality hub genes and significantly enriched pathways (MAPK, Ras, and ErbB signaling pathways) were identified by using gene functional assignment and enrichment analyses. Six genes (
conclusionThe current study identified a panel of candidate genes and important pathways, which might help us deepen our understanding of the underlying mechanism of PTSD at the molecular level. However, further studies are warranted to discover the critical regulatory mechanism of these genes
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