Evidence map›Paper›PMID 33391977›Full record

ReviewNanotheranostics2021

Noninvasive Imaging of Cancer Immunotherapy.

Omar Abousaway, Taha Rakhshandehroo, Annick D Van den Abbeele, Moritz F Kircher, Mohammad Rashidian

Abstract readReview
In one paragraph

Review in Nanotheranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Imaging the hallmarks of cancer.Nature reviews. Cancer · 2026
    Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Imaging of tumor-associated macrophage dynamics during immunotherapy using a CD163-specific nanobody-based immunotracer.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  8. Why Current Detection of Vascular Calcification Falls Short and How to Improve on It.TH open : companion journal to thrombosis and haemostasis · 2024
    Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Review
  14. Visualizing T-Cell Responses: The T-Cell PET Imaging Toolbox.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2022
    Review
  15. Article
  16. Review
  17. Article
  18. Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Omar AbousawayDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Taha RakhshandehrooDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Annick D Van den AbbeeleDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Moritz F KircherDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.
Mohammad RashidianDepartment of Imaging, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA, 02215, USA.

Funding

Noninvasive monitoring and evaluation of anti-tumor responses as a predictive toolK22CA226040 · NCI · DANA-FARBER CANCER INST · PI RASHIDIAN, MOHAMMAD · 2019 to 2021
$574k
NCI NIH HHS K22 CA226040
6 · The paper itself

Abstract

Immunotherapy has revolutionized the treatment of several malignancies. Notwithstanding the encouraging results, many patients do not respond to treatments. Evaluation of the efficacy of treatments is challenging and robust methods to predict the response to treatment are not yet available. The outcome of immunotherapy results from changes that treatment evokes in the tumor immune landscape. Therefore, a better understanding of the dynamics of immune cells that infiltrate into the tumor microenvironment may fundamentally help in addressing this challenge and provide tools to assess or even predict the response. Noninvasive imaging approaches, such as PET and SPECT that provide whole-body images are currently seen as the most promising tools that can shed light on the events happening in tumors in response to treatment. Such tools can provide critical information that can be used to make informed clinical decisions. Here, we review recent developments in the field of noninvasive cancer imaging with a focus on immunotherapeutics and nuclear imaging technologies and will discuss how the field can move forward to address the challenges that remain unresolved.

Indexed as

ImmunotherapyHumansNeoplasmsTumor MicroenvironmentCancer ImmunotherapyNoninvasive Imaging

Identifiers

PMID33391977
PMCPMC7738948

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.