Evidence map›Paper›PMID 33391975›Full record

ArticleNanotheranostics2021

Intraoperative assessment and postsurgical treatment of prostate cancer tumors using tumor-targeted nanoprobes.

James Teh, Manisha Tripathi, Derek Reichel, Bien Sagong, Ricardo Montoya, Yi Zhang, Shawn Wagner, Rola Saouaf, Leland W K Chung, J Manuel Perez

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nanotheranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 59% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

James TehDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Manisha TripathiDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Derek ReichelDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Bien SagongDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Ricardo MontoyaDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Yi ZhangBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Shawn WagnerBiomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Rola SaouafS. Mark Taper Foundation Imaging Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Leland W K ChungDepartment of Medicine, Uro-Oncology Research Program, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
J Manuel PerezDepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
Cedars-Sinai Medical Center · USTexas Tech University Health Sciences Center · US

Funding

Polymeric nanoparticles with imaging capability for therapeutic peptide deliveryR01EB019288 · NIBIB · UNIVERSITY OF CENTRAL FLORIDA · PI KHALED, ANNETTE R, PEREZ, J MANUEL · 2014 to 2017
$1.2M
NIBIB NIH HHS R01 EB019288
6 · The paper itself

Abstract

Successful visualization of prostate cancer (PCa) tumor margins during surgery remains a major challenge. The visualization of these tumors during surgery via near infrared fluorescence (NIRF) imaging would greatly enhance surgical resection, minimizing tumor recurrence and improving outcome. Furthermore, chemotherapy is typically administered to patients after surgery to treat any missed tumor tissue around the surgical area, minimizing metastasis and increasing patient survival. For these reasons, a theranostics fluorescent nanoparticle could be developed to assist in the visualization of PCa tumor margins, while also delivering chemotherapeutic drug after surgery.

Indexed as

NanoparticlesHumansIntraoperative CareMaleProstatic Neoplasmsheptamethine cyanineimage-guided therapyiron oxide nanoparticlesnear infrared fluorescence imagingprostate cancer

Identifiers

PMID33391975
PMCPMC7738944
OpenAlexW3096011703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.