Evidence map›Paper›PMID 33391540›Full record

ArticleTheranostics2021

Phosphoproteomics identify arachidonic-acid-regulated signal transduction pathways modulating macrophage functions with implications for ovarian cancer.

Raimund Dietze, Mohamad K Hammoud, María Gómez-Serrano, Annika Unger, Tim Bieringer, Florian Finkernagel, Anna M Sokol, Andrea Nist, Thorsten Stiewe, Silke Reinartz and 6 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
1.7field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 45 citations in OpenAlex.

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  17. Bioinformatics analysis revealsTranslational cancer research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 2 institutions in 1 country.

Raimund DietzeTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Mohamad K HammoudTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
María Gómez-SerranoTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Annika UngerTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Tim BieringerTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Florian FinkernagelTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Anna M SokolBiomolecular Mass Spectrometry, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Andrea NistGenomics Core Facility, Philipps University, Marburg, Germany.
Thorsten StieweGenomics Core Facility, Philipps University, Marburg, Germany.
Silke ReinartzTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Viviane PonathInstitute for Tumor Immunology, Philipps University, Marburg, Germany.
Christian PreußerInstitute for Tumor Immunology, Philipps University, Marburg, Germany.
Elke Pogge von StrandmannInstitute for Tumor Immunology, Philipps University, Marburg, Germany.
Sabine Müller-BrüsselbachTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Johannes GraumannBiomolecular Mass Spectrometry, Max-Planck-Institute for Heart and Lung Research, Bad Nauheim, Germany.
Rolf MüllerTranlational Oncology Group, Center for Tumor Biology and Immunology, Philipps University, Marburg, Germany.
Max Planck Institute for Heart and Lung Research · DEPhilipps University of Marburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Arachidonic acid (AA) is a polyunsaturated fatty acid present at high concentrations in the ovarian cancer (OC) microenvironment and associated with a poor clinical outcome. In the present study, we have unraveled a potential link between AA and macrophage functions.

Indexed as

Arachidonic AcidCalciumExtracellular VesiclesFemaleGroup II Phospholipases A2HumansMacrophagesNeoplasm Recurrence, LocalOvarian NeoplasmsPhosphorylationReactive Oxygen SpeciesSignal TransductionTranscription, GeneticTumor MicroenvironmentArachidonic AcidCalciumGroup II Phospholipases A2Reactive Oxygen Speciesarachidonic acidmacropinocytosisovarian cancerphosphoproteomics

Identifiers

PMID33391540
PMCPMC7738879
OpenAlexW3111339094

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.