Evidence map›Paper›PMID 33391501›Full record

ArticleTheranostics2021

Brain-derived neurotrophic factor precursor in the immune system is a novel target for treating multiple sclerosis.

Zhao-Lan Hu, Cong Luo, Plinio Reinaldo Hurtado, Hui Li, Shuang Wang, Bo Hu, Jun-Mei Xu, Yang Liu, Shi-Qing Feng, Ernesto Hurtado-Perez and 4 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 35 citations in OpenAlex.

  1. Article
  2. Article
  3. P75iScience · 2025
    Article
  4. Review
  5. Article
  6. Mechanism by which hyperglycemia regulates precursor of brainZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2024
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Expression of proBDNF/p75Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
    Article
  12. The Role of BDNF in Multiple Sclerosis Neuroinflammation.International journal of molecular sciences · 2023
    Review
  13. Article
  14. Review
  15. Article
  16. Up-Regulation of ProBDNF/p75Journal of inflammation research · 2023
    Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Zhao-Lan HuDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, 139 Ren-Min Central Road, Changsha City, Hunan 410011, China.
Cong LuoDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, 139 Ren-Min Central Road, Changsha City, Hunan 410011, China.
Plinio Reinaldo HurtadoDepartment of Renal Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Hui LiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, 139 Ren-Min Central Road, Changsha City, Hunan 410011, China.
Shuang WangDepartment of Medical Research Center and Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China.
Bo HuDepartment of Neurology, Xiangya Hospital of Central South University, Changsha, Hunan 410008, China.
Jun-Mei XuDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, 139 Ren-Min Central Road, Changsha City, Hunan 410011, China.
Yang LiuSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Shi-Qing FengDepartment of Orthopedics, Tianjin General Hospital, Tianjin Medical University, Tianjin 300070, China.
Ernesto Hurtado-PerezDepartment of Renal Medicine, Royal Adelaide Hospital, Adelaide, SA 5000, Australia.
Kang ChenPerinatology Research Branch, Eunice Kennedy Shriver NICHD, National Institutes of Health, Department of Obstetrics and Gynecology, Wayne State University, Detroit, Michigan 48201, USA.
Xin-Fu ZhouSchool of Pharmacy and Medical Sciences, Division of Health Sciences, University of South Australia, Adelaide, SA 5000, Australia.
Chang-Qi LiDepartment of Anatomy and Neurobiology, School of Basic Medical Science, Central South University, Changsha City, Hunan 410011, China.
Ru-Ping DaiDepartment of Anesthesiology, The Second Xiangya Hospital, Central South University, 139 Ren-Min Central Road, Changsha City, Hunan 410011, China.
Central South University · CNRoyal Adelaide Hospital · AUUniversity of South Australia · AUXiangya Hospital Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBrainBrain-Derived Neurotrophic FactorCase-Control StudiesDisease Models, AnimalEncephalomyelitis, Autoimmune, ExperimentalHumansLeukocytesLeukocytes, MononuclearMiceMice, Inbred C57BLMultiple SclerosisProtein PrecursorsSpinal CordBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor precursorProtein PrecursorsantibodiesB cellbrain-derived neurotrophic factorimmune responseimmunotherapyMultiple sclerosisproBDNF

Identifiers

PMID33391501
PMCPMC7738849
OpenAlexW3095167335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.