Evidence map›Paper›PMID 33391499›Full record

ArticleTheranostics2021

Expansion of murine and human olfactory epithelium/mucosa colonies and generation of mature olfactory sensory neurons under chemically defined conditions.

Wenwen Ren, Li Wang, Xiujuan Zhang, Xiaoyu Feng, Liujing Zhuang, Nan Jiang, Rui Xu, Xuewen Li, Ping Wang, Xicai Sun and 2 more

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Construction ofiScience · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Olfactory models as a platform for neuroscience research.Frontiers in cellular neuroscience · 2026
    Review
  7. Article
  8. Article
  9. Chemosensory tobacco product toxicology part 2: toxicological testing, assays, and state of the science.Toxicological sciences : an official journal of the Society of Toxicology · 2025
    Review
  10. Review
  11. Article
  12. Strategies to Develop Regenerative Medicine Approaches for Olfactory Disorders.Clinical and experimental otorhinolaryngology · 2025
    Review
  13. Organoid models for chemosensing cell studies.American journal of physiology. Cell physiology · 2025
    Review
  14. Article
  15. Review
  16. Review
  17. Frontiers in cell and developmental biology · 2025
    Article
  18. Axonal Regrowth of Olfactory Sensory Neurons In Vitro.International journal of molecular sciences · 2023
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Wenwen RenDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Li WangDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Xiujuan ZhangDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Xiaoyu FengSchool of Life Sciences, Shanghai University, Shanghai, China 200444.
Liujing ZhuangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China 310027.
Nan JiangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China 310027.
Rui XuSchool of Life Sciences, Shanghai University, Shanghai, China 200444.
Xuewen LiSchool of Life Sciences, Shanghai University, Shanghai, China 200444.
Ping WangBiosensor National Special Laboratory, Key Laboratory for Biomedical Engineering of Education Ministry, Department of Biomedical Engineering, Zhejiang University, Hangzhou, China 310027.
Xicai SunDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Hongmeng YuDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Yiqun YuDepartment of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University, Shanghai, China 200031.
Eye & ENT Hospital of Fudan University · CNShanghai University · CNMinistry of Health · OM

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Olfactory dysfunctions, including hyposmia and anosmia, affect ~100 million people around the world and the underlying causes are not fully understood. Degeneration of olfactory sensory neurons and incapacity of globose basal cells to generate olfactory sensory neurons are found in elder people and patients with smell disorders. Thus, olfactory stem cell may function as a promising tool to replace inactivated globose basal cells and to generate sensory neurons.

Indexed as

NeurogenesisAlanineAnimalsAzepinesCell DifferentiationCell ProliferationFemaleHumansMaleMiceOlfactory MucosaOlfactory Receptor NeuronsPyridinesPyrimidinesReceptors, G-Protein-CoupledStem CellsAlanineAzepinesChir 99021LGR5 protein, humanN2-((2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl)-N1-((7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo(b,d)azepin-7-yl)-L-alaninamidePyridinesPyrimidinesReceptors, G-Protein-CoupledcolonyLgr5Olfactory epithelium/mucosaolfactory sensory neuronsthree-dimensional culture

Identifiers

PMID33391499
PMCPMC7738855
OpenAlexW3097347715

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.