Evidence map›Paper›PMID 33391488›Full record

ArticleTheranostics2021

Inter and intra-tumor somatostatin receptor 2 heterogeneity influences peptide receptor radionuclide therapy response.

Danny Feijtel, Gabriela N Doeswijk, Nicole S Verkaik, Joost C Haeck, Daniela Chicco, Carmelina Angotti, Mark W Konijnenberg, Marion de Jong, Julie Nonnekens

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 42 citations in OpenAlex.

  1. Trial
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  14. Predicting the Response of Patients Treated withJournal of medical signals and sensors · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Danny FeijtelDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Gabriela N DoeswijkDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Nicole S VerkaikDepartment of Molecular Genetics, Erasmus MC Rotterdam, The Netherlands.
Joost C HaeckDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Daniela ChiccoAdvanced Accelerator Applications SA, a Novartis Company, Erasmus MC Rotterdam, The Netherlands.
Carmelina AngottiAdvanced Accelerator Applications SA, a Novartis Company, Erasmus MC Rotterdam, The Netherlands.
Mark W KonijnenbergDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Marion de JongDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Julie NonnekensDepartment of Radiology and Nuclear Medicine, Erasmus MC Rotterdam, The Netherlands.
Erasmus MC · NLAdvanced Applications (United States) · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Patients with neuroendocrine tumors (NETs) can be treated with peptide receptor radionuclide therapy (PRRT). Here, the somatostatin analogue octreotate radiolabeled with lutetium-177 is targeted to NET cells by binding to the somatostatin receptor subtype 2 (SST

Indexed as

AnimalsApoptosisCell ProliferationCoordination ComplexesHumansMiceMice, Inbred BALB CMice, NudeOctreotidePancreatic NeoplasmsRadiopharmaceuticalsReceptors, SomatostatinTissue DistributionTomography, Emission-Computed, Single-PhotonTumor Cells, CulturedXenograft Model Antitumor Assays177Lu-DOTA-octreotateCoordination ComplexesOctreotideRadiopharmaceuticalsReceptors, SomatostatinSSTR2 protein, humanDNA damage responseneuroendocrine tumorsPeptide receptor radionuclide therapyradiobiologysomatostatin receptor subtype 2

Identifiers

PMID33391488
PMCPMC7738856
OpenAlexW3097144231

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.