Evidence map›Paper›PMID 33391271›Full record

ArticleFrontiers in immunology2020

Increased Frequency of Memory CD4+ T-Cell Responses in Individuals With Previously Treated Extrapulmonary Tuberculosis.

Beatriz Barreto-Duarte, Timothy R Sterling, Christina T Fiske, Alexandre Almeida, Cynthia H Nochowicz, Rita M Smith, Louise Barnett, Christian Warren, Amondrea Blackman, Jose Roberto Lapa E Silva and 2 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. Host- and pathogen-related determinants of pulmonaryEuropean respiratory review : an official journal of the European Respiratory Society · 2026
    Review
  2. Article
  3. iScience · 2023
    Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 2 countries.

Beatriz Barreto-DuarteInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Timothy R SterlingDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Christina T FiskeDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Alexandre AlmeidaFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Cynthia H NochowiczDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Rita M SmithDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Louise BarnettDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Christian WarrenDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Amondrea BlackmanDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Jose Roberto Lapa E SilvaFaculdade de Medicina, Universidade Federal do Rio de Janeiro, Rio de Janeiro, Brazil.
Bruno B AndradeInstituto Gonçalo Moniz, Fundação Oswaldo Cruz, Salvador, Brazil.
Spyros A KalamsDivision of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · USUniversidade Federal do Rio de Janeiro · BRFundação Oswaldo Cruz · BRUniversidade Federal da Bahia · BR

Funding

CCASAnet: Caribbean, Central and South America NetworkU01AI069923 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Pedro Enrique Cahn, Jessica L Castilho · 2006 to 2026
$41.6M
Tennessee CFAR: Implementation of Culturally Responsive Trauma-Informed Care with Youth with HIV in Memphis, TNP30AI110527 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Chandravanu Dash · 2015 to 2026
$27.5M
Toll-like Receptor 2, Vitamin D, and Extrapulmonary TuberculosisK23AI091692 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI FISKE, CHRISTINA A. · 2011 to 2015
$540k
Molecular analysis of the adaptive immune response to tuberculosisR21AI127129 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KALAMS, SPYROS A · 2016 to 2017
$432k
NIAID NIH HHS K23 AI091692NIAID NIH HHS P30 AI110527NIAID NIH HHS R21 AI127129NIAID NIH HHS U01 AI069923
6 · The paper itself

Abstract

Extrapulmonary TB (EPTB) occurs with increased frequency in persons with underlying immunodeficiency. Even after recovery from acute illness, differences in immune phenotype and activation persist. Studies defining characteristics of immune responses after recovery from extrapulmonary TB may provide insights into factors that increase TB risk. We performed two case-control studies (in the United States and Brazil) among HIV-seronegative adults with previous EPTB (n = 9; 25), previous pulmonary TB (n = 7; 25), latent

Indexed as

Immunologic MemoryAdultAgedAntigens, BacterialAntitubercular AgentsBacterial ProteinsBrazilCase-Control StudiesCD4-Positive T-LymphocytesCell ProliferationCells, CulturedCytokinesFemaleHost-Pathogen InteractionsHumansLymphocyte ActivationAntigens, BacterialAntitubercular AgentsBacterial ProteinsCFP-10 protein, Mycobacterium tuberculosisCytokinesESAT-6 protein, Mycobacterium tuberculosisCD4+ T cellcytokineextrapulmonary tuberculosismemory T-cell responsestuberculosis

Identifiers

PMID33391271
PMCPMC7774017
OpenAlexW3113267751

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.