ArticleFrontiers in psychiatry2020
Metabolic Profiling in Bipolar Disorder Patients During Depressive Episodes.
Article in Frontiers in psychiatry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- Divergent Patterns of Genetic Overlap Between Severe Mental Disorders and Metabolic Markers.The American journal of psychiatry · 2026Article
- A multi-omics analysis of gut bacteriome, virome, and serum metabolome in bipolar depression.Npj mental health research · 2026Article
- Biomarkers of bipolar disorder in omics and neuroimaging.Journal of pharmaceutical analysis · 2025Review
- Identification of peripheral biomarkers through metabolomic analysis in patients with bipolar disorder treated with mood stabilizers: an exploratory study.The international journal of neuropsychopharmacology · 2025Article
- Amino acids, purines, and pyrimidines as potential biochemical markers of bipolar disorder - current state of knowledge.Postepy psychiatrii neurologii · 2025Review
- Alterations of Blood Plasma Metabolites, Including Kynurenine and Tryptophan, in Bipolar Disorder.Neuropsychiatric disease and treatment · 2025Article
- Translational bioinformatics and data science for biomarker discovery in mental health: an analytical review.Briefings in bioinformatics · 2024Review
- Metabolomic Profiling of Bipolar Disorder byMetabolites · 2023Article
- Comparing the metabolic pathways of different clinical phases of bipolar disorder through metabolomics studies.Frontiers in psychiatry · 2023Article
- Search for serum biomarkers in patients with bipolar disorder and major depressive disorder using metabolome analysis.Frontiers in psychiatry · 2023Article
- Metabolomic biomarkers related to non-suicidal self-injury in patients with bipolar disorder.BMC psychiatry · 2022Article
- Integrated network pharmacology and hepatic metabolomics to reveal the mechanism ofFrontiers in cell and developmental biology · 2022Article
- Pre- and Post-treatment Levels of Plasma Metabolites in Patients With Bipolar Depression.Frontiers in psychiatry · 2021Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bipolar disorder (BD) is a common and debilitating mental disorder. Bipolar depression is the main episode of BD. Furthermore, there are no objective biomarkers available for diagnosing the disorder. In this research, a Nuclear Magnetic Resonance (NMR) spectroscopy based on a metabonomics technique was used to analyze serum samples from 37 patients with bipolar depression and 48 healthy control participants to determine potential biomarkers for bipolar depression. In total, seven different metabolites were identified that could effectively distinguish patients from healthy controls. The metabolites indicated that disturbances of amino acid and energy metabolisms might be involved in the pathogenesis of BD. Finally, a panel consisting of four potential biomarkers (lactate, trimethylamine oxide, N-acetyl glycoprotein, and α-glucose) was identified, which showed a higher combined diagnostic ability with an area under the curve of 0.893. Our findings may contribute to the development of an objective method for diagnosing bipolar depression.
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