Evidence map›Paper›PMID 33391029›Full record

ArticleFrontiers in physiology2020

Blood Pressure Increase and Microvascular Dysfunction Accelerate Arterial Stiffening in Children: Modulation by Physical Activity.

Giulia Lona, Christoph Hauser, Sabrina Köchli, Denis Infanger, Katharina Endes, Oliver Faude, Henner Hanssen

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03085498 (Sportcheck Follow-Up), which is not on this map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
1.6field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03085498 completednot on this map

Sportcheck Follow-Up: Physical Fitness, Cardiovascular and Psychosocial Health in Primary School Childen

TypeobservationalSponsorUniversity of BaselRan2017 to 2018Enrolled280ConditionsCardiovascular Diseases, Childhood Obesity, HypertensionArmsNo intervention
3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 21 citations in OpenAlex.

  1. Pooled it
  2. Global research on 24-hour movement behaviours guidelines in children and adolescents: a systematic review.The international journal of behavioral nutrition and physical activity · 2025
    Pooled it
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  10. Vascular ageing: moving from bench towards bedside.European journal of preventive cardiology · 2023
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Giulia LonaDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Christoph HauserDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Sabrina KöchliDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Denis InfangerDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Katharina EndesDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Oliver FaudeDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
Henner HanssenDepartment of Sport, Exercise and Health, Medical Faculty, University of Basel, Basel, Switzerland.
University of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAtherosclerotic remodeling starts early in life and can accelerate in the presence of cardiovascular risk (CV) factors. Regular physical activity (PA) can mitigate development of large and small artery disease during lifespan. We aimed to investigate the association of changes in body mass index (BMI), blood pressure (BP), PA behavior and retinal microvascular diameters with large artery pulse wave velocity (PWV) in prepubertal children over 4 years.

methodsThe school-based prospective cohort study included 262 children initially aged 6-8 years, assessing the above CV risk factors and retinal vessels by standardized procedures at baseline (2014) and follow-up (2018). PWV was assessed by an oscillometric device at follow-up.

resultsChildren with increased systolic BP over 4 years showed higher PWV at follow-up (β [95% CI] 0.006 [0.002 to 0.011] mmHg per unit,

conclusionIncrease in systolic BP and progression of microvascular dysfunction were associated with higher PWV after 4 years. Children with increasing levels of vigorous PA were found to have lower PWV at follow-up. Habitual vigorous PA has the potential to decelerate the process of early vascular aging in children and may thus help counteract CV disease development later in life. CLINICAL

trial registrationClinicalTrials.gov, Identifier: NCT03085498.

Indexed as

arterial stiffnessblood pressurecardiovascular riskchildhood healthphysical activityretinal vessel diameters

Identifiers

PMID33391029
PMCPMC7773656
OpenAlexW3112039773

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.