Evidence map›Paper›PMID 33391023›Full record

ArticleFrontiers in physiology2020

The Role of CaMKII Overexpression and Oxidation in Atrial Fibrillation-A Simulation Study.

Wei Wang, Weijian Shen, Shanzhuo Zhang, Gongning Luo, Kuanquan Wang, Yong Xu, Henggui Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.6field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Wei WangShenzhen Key Laboratory of Visual Object Detection and Recognition, Harbin Institute of Technology, Shenzhen, China.
Weijian ShenBiological Physics Group, School of Physics and Astronomy, The University of Manchester, Manchester, United Kingdom.
Shanzhuo ZhangDepartment of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Gongning LuoDepartment of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Kuanquan WangDepartment of Computer Science and Technology, Harbin Institute of Technology, Harbin, China.
Yong XuShenzhen Key Laboratory of Visual Object Detection and Recognition, Harbin Institute of Technology, Shenzhen, China.
Henggui ZhangPeng Cheng Lab, Shenzhen, China.
Harbin Institute of Technology · CNPeng Cheng Laboratory · CNUniversity of Manchester · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This simulation study aims to investigate how the Calcium/calmodulin-dependent protein kinase II (CaMKII) overexpression and oxidation would influence the cardiac electrophysiological behavior and its arrhythmogenic mechanism in atria. A new-built CaMKII oxidation module and a refitted CaMKII overexpression module were integrated into a mouse atrial cell model for analyzing cardiac electrophysiological variations in action potential (AP) characteristics and intracellular Ca

Indexed as

atrial fibrillationcalcium cyclingCaMKII overexpressionCaMKII oxidationcardiac modeling

Identifiers

PMID33391023
PMCPMC7775483
OpenAlexW3113287595

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.