Evidence map›Paper›PMID 33390966›Full record

ArticleFrontiers in pharmacology2020

In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an

Dahara Keyse Carvalho Silva, Jessicada Silva Teixeira, Diogo Rodrigo Magalhães Moreira, Tiago Fernandes da Silva, Eliezer Jesus de Lacerda Barreiro, Humberto Fonseca de Freitas, Samuel Silva da Rocha Pita, André Lacerda Braga Teles, Elisalva Teixeira Guimarães, Milena Botelho Pereira Soares

Open access · goldAbstract read
In one paragraph

Article in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.1field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. New Thieno[3,2-Life (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Dahara Keyse Carvalho SilvaDepartamento de Ciências da Vida, Núcleo de Estudo e Pesquisa em Histopatologia, Universidade Estadual da Bahia (UNEB), Salvador, Brazil.
Jessicada Silva TeixeiraDepartamento de Ciências da Vida, Núcleo de Estudo e Pesquisa em Histopatologia, Universidade Estadual da Bahia (UNEB), Salvador, Brazil.
Diogo Rodrigo Magalhães MoreiraLaboratório de Engenharia Tecidual e Imunofarmacologia, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.
Tiago Fernandes da SilvaLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Eliezer Jesus de Lacerda BarreiroLaboratório de Avaliação e Síntese de Substâncias Bioativas (LASSBio®), Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
Humberto Fonseca de FreitasLaboratório de Bioinformática e Modelagem Molecular (LaBiMM), Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
Samuel Silva da Rocha PitaLaboratório de Bioinformática e Modelagem Molecular (LaBiMM), Faculdade de Farmácia, Universidade Federal da Bahia, Salvador, Brazil.
André Lacerda Braga TelesDepartamento de Ciências da Vida, Laboratório de Modelagem Molecular Medicinal e Toxicológica, Universidade Estadual da Bahia (UNEB), Salvador, Brazil.
Elisalva Teixeira GuimarãesDepartamento de Ciências da Vida, Núcleo de Estudo e Pesquisa em Histopatologia, Universidade Estadual da Bahia (UNEB), Salvador, Brazil.
Milena Botelho Pereira SoaresLaboratório de Engenharia Tecidual e Imunofarmacologia, Instituto Gonçalo Moniz, Fundação Oswaldo Cruz (FIOCRUZ), Salvador, Brazil.
Fundação Oswaldo Cruz · BRUniversidade Federal da Bahia · BRUniversidade Federal do Rio de Janeiro · BRServiço Nacional de Aprendizagem Industrial · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis are group of neglected diseases with worldwide distribution that affect about 12 million people. The current treatment is limited and may cause severe adverse effects, and thus, the search for new drugs more effective and less toxic is relevant. We have previously investigated the immunomodulatory effects of LASSBio-1386, an

Indexed as

LASSBio-1386Leishmania amazonensisN-acyl hydrazonesphosphodiesterasetreatment

Identifiers

PMID33390966
PMCPMC7772393
OpenAlexW3111969945

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.