ReviewFrontiers in pharmacology2020
Postoperative Ileus and Postoperative Gastrointestinal Tract Dysfunction: Pathogenic Mechanisms and Novel Treatment Strategies Beyond Colorectal Enhanced Recovery After Surgery Protocols.
Review in Frontiers in pharmacology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07713472 (Benefits of Abdominal Massage After Colon Surgery for Cancer Following an ERAS Protocol), which is not on this map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Benefits of Abdominal Massage After Colon Surgery for Cancer Following an ERAS Protocol (MATRAC_Ter): a Multicenter, Prospective, Randomized Clinical Trial
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 148 citations in OpenAlex.
- Efficacy of Acupuncture in Postoperative Recovery for Gastrointestinal Tumors: A Systematic Review and Meta-Analysis.Chinese journal of integrative medicine · 2026Pooled it
- Effect of postoperative coffee consumption on gastrointestinal function after cesarean section, a systematic review and meta-analysis of randomized controlled trials.BMC public health · 2026Pooled it
- Efficacy and safety of therapeutic means for postoperative ileus: an umbrella review of meta-analyses.Langenbeck's archives of surgery · 2025Pooled it
- Use of Acetylcholinesterase Inhibitors in Reducing Time to Gastrointestinal Function Recovery following Abdominal Surgery: A Systematic Review.Digestive surgery · 2024Pooled it
- Effects of remote ischemic preconditioning on postoperative gastrointestinal function in patients undergoing off-pump coronary artery bypass grafting: a randomized controlled trial.BMC anesthesiology · 2026Trial
- Effects of Oxycodone versus Sufentanil-Based Intravenous Patient-Controlled Multimodal Analgesia on Early Gastrointestinal Recovery and Pain After Laparoscopic Colorectal Cancer Surgery: A Randomized Double-Blind Trial.Journal of pain research · 2026Trial
- Effect of Oliceridine Fumarate for Patient-Controlled Intravenous Analgesia on Gastrointestinal Function in Laparoscopic Radical Gastrectomy Surgery: A Randomized, Double-Blind, Controlled Trial.Drug design, development and therapy · 2026Trial
- Trial
- Comparison of Bilateral Rectus Sheath Block and Thoracic Epidural Analgesia for Postoperative Pain Control After Open Gastrectomy: A Randomized Controlled Trial.Medicina (Kaunas, Lithuania) · 2025Trial
- Study of penehyclidine for the prevention of postoperative nausea and vomiting following laparoscopic sleeve gastrectomy under general anesthesia: a randomized, prospective, double-blind trial.Journal of anesthesia · 2025Trial
- Integrated metabolomic insights into the mechanism ofFrontiers in immunology · 2025Trial
- Comparison of the effect of chewing gum with routine method on ileus after burns: a randomized clinical trial.BMC research notes · 2024Trial
- Abdominal massage to prevent ileus after colorectal surgery. A single-center, prospective, randomized clinical trial: the MATRAC Trial.Techniques in coloproctology · 2024Trial
- Effects of intraoperative esketamine addition on gastrointestinal function after benign gynaecological laparoscopic surgery: a double-blind, randomized controlled study.BMC anesthesiology · 2023Trial
- Effect of prucalopride to improve time to gut function recovery following elective colorectal surgery: randomized clinical trial.The British journal of surgery · 2022Trial
- A randomised pilot trial of virtual reality-based relaxation for enhancement of perioperative well-being, mood and quality of life.Scientific reports · 2022Trial
- Nurses' learning curves for ultrasound assessment of gastric content: A prospective cohort study.International journal of nursing studies advances · 2026Article
- Early postoperative hypophosphatemia is an independent predictor of ileus after transforaminal lumbar interbody fusion: a multicenter retrospective cohort study.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Article
- Incidence and outcomes of postoperative paralytic ileus after cytoreductive surgery with HIPEC: A population-based study.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026Article
- Optimizing pain management: a systematic review and meta-analysis of opioid-sparing and opioid-free analgesia in minimally invasive colorectal surgery.Updates in surgery · 2026Review
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Postoperative ileus (POI) and postoperative gastrointestinal tract dysfunction (POGD) are well-known complications affecting patients undergoing intestinal surgery. GI symptoms include nausea, vomiting, pain, abdominal distention, bloating, and constipation. These iatrogenic disorders are associated with extended hospitalizations, increased morbidity, and health care costs into the billions and current therapeutic strategies are limited. This is a narrative review focused on recent concepts in the pathogenesis of POI and POGD, pipeline drugs or approaches to treatment. Mechanisms, cellular targets and pathways implicated in the pathogenesis include gut surgical manipulation and surgical trauma, neuroinflammation, reactive enteric glia, macrophages, mast cells, monocytes, neutrophils and ICC's. The precise interactions between immune, inflammatory, neural and glial cells are not well understood. Reactive enteric glial cells are an emerging therapeutic target that is under intense investigation for enteric neuropathies, GI dysmotility and POI. Our review emphasizes current therapeutic strategies, starting with the implementation of colorectal enhanced recovery after surgery protocols to protect against POI and POGD. However, despite colorectal enhanced recovery after surgery, it remains a significant medical problem and burden on the healthcare system. Over 100 pipeline drugs or treatments are listed in Clin.Trials.gov. These include 5HT
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.